• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Rotavirus vaccine associated with increased risk of intussusception

byKhang DinhandAndrew Bishara
February 8, 2014
in Gastroenterology, Infectious Disease, Pediatrics, Public Health, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD

1.  In the first 7 days after administration of the first dose, the pentavalent rotavirus vaccine, RotaTeq, was associated with an increased risk of intussusception by 1.5 excess cases per 100,000 doses given.

2. The relative risk of intussusceptions was roughly ten times lower for the pentavalent rotavirus vaccine as compared to the monovalent vaccine, Rotarix. 

Evidence Rating: 2 (Good)

Study Rundown: Rotavirus is a leading cause of diarrhea in children in developed countries.  The advent of a live-attenuated oral rotavirus vaccine has prevented over an estimated 50,000 hospitalizations per year.  However, an early iteration of the vaccine has also been associated with an increased risk of intussusception in young children.  Previously, there existed some equipoise regarding the risk of the monovalent vaccine, Rotashield (RV1), and the pentavalent vaccine, RotaTeq (RV5).  This study examined the rates of intussusception in children 5.0 to 36.9 weeks of age who received either RV1 or RV5 from January 2004 to September 2011.  Overall, the authors found that there were 1.5 excess cases of intussusception per 100,000 doses in children who received RV5, with no significant change in attributable risk after subsequent doses.  Because the great majority of children receive RV5 in the US, there was not enough data to statistically power the analysis of risk in children who receive RV1.  However, the authors estimate that RV1 is associated with an excess 7.3 cases per 100,000 doses.

Click to read the study in NEJM

Relevant reading: Uptake, Impact, and Effectiveness of Rotavirus Vaccination in the United States: Review of the First 3 Years of Postlicensure Data

RELATED REPORTS

Subsidization of supermarkets may help reduce obesity risk in children

Intensive program to support caretaker access to food improves diet of children

Meaning-centered play may increase spiritual sensitivity of children

In-Depth [retrospective study]: In this retrospective study, the rates of intussusception after administration of oral rotavirus vaccines in children aged 5.0 to 34.9 months were reviewed.  The study included 1,277,556 doses of RV5 and 103,098 doses of RV1.  Confirmed cases of intussusception were identified using the Brighton Collaboration criteria for diagnostic certainty.  Of 343 potential cases of intussusception, the authors identified 124 confirmed cases.  The first dose of RV5 was associated with an excess 1.1 cases of intussusceptions (95% CI, 0.3 to 2.7) in the 7-day risk window and 1.5 (95% CI, 0.2 to 3.2) in the 21-day risk window.  Subsequent doses of the vaccine were not associated with significantly increased risk.  There were not enough cases to apply self-controlled risk-interval (SCRI) analysis in the RV1 group but a cohort analysis attributed an excess 7.3 cases (95% CI, 0.8 to 22.5) after dose 2.  This study primarily used a SCRI analysis to compare the occurrence of intussusception in day 1 to 7 or day 1 to 21 risk interval to that in day 22 to 42 control interval.  Because there were not enough cases for statistical significance using SCRI, cohort analysis was done for RV1 data.  In the SCRI analysis, the dependence of rates of intussusception on age was normalized using well-curated background rates while a quadratic model of age-dependent risk was used for adjustment in the cohort analysis.

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.

Tags: childrendeveloped countriesdiarrheaintussusceptionmonovalentoral vaccinepentavalen vaccineretrospective studyRotarixRotaTeqrotavirus
Previous Post

Evidence suggests H7N9 avian influenza transmitted through animal contact

Next Post

Elective induction may increase risk of C-section in obese women

RelatedReports

Meeting families, demographic information affect child abuse work-up
Pediatrics

Subsidization of supermarkets may help reduce obesity risk in children

June 27, 2022
Eating in the absence of hunger linked to toddler obesity
Pediatrics

Intensive program to support caretaker access to food improves diet of children

June 24, 2022
Adolescent mothers in protective care more likely to have their children placed in care
Pediatrics

Meaning-centered play may increase spiritual sensitivity of children

June 21, 2022
Wellness

Wellness Check: Spirituality

June 21, 2022
Next Post
C-section surgical techniques yield equivalent outcomes

Elective induction may increase risk of C-section in obese women

Symptom-triggered benzodiazepine treatment for alcohol withdrawal [Classics Series]

Caffeine intake among youth remains stable, but sources vary

Caffeine intake among youth remains stable, but sources vary

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
  • FOLFOX combined with nivolumab and trastuzumab in ERBB2-positive esophagogastric adenocarcinoma is an emerging therapy option
  • Early initiation of poststernotomy cardiac rehabilitation exercise training is effective and safe
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.