• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Second-line immunosuppression associated with worse outcomes for immune-related adverse events in melanoma

byMinjee Kim
November 17, 2022
in StudyGraphics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Median overall survival was longer in patients receiving steroid-only treatment for adverse events associated with immune response.

2. Patients receiving steroids plus any immunosuppressant for treatment of immune-related adverse events had reduced median progression free survival.

Evidence Rating Level: 2 (Good)

Study Rundown: Immune-related adverse events (irAEs) are hypothesized to arise secondary to immune activation during treatment of cancers like melanoma with immune checkpoint inhibitors (ICIs). This study investigated the association of adverse event management with both overall and progression free survival (OS and PFS, respectively) in patients receiving ipilimumab-nivolumab combination therapy. It was found that median OS was longer in patients who only had steroids as treatment for their irAEs, when compared to patients receiving immunosuppressants as well. Similarly, patients taking anti-TNF immunosuppressants in addition to steroid treatment had reduced OS compared to steroids-only treatment, but patients receiving any other immunosuppressants did not. The median PFS for patients on steroid-only treatment was greater than the median PFS of patients receiving steroids and second line immunosuppressants. Median PFS on either immunosuppressant was reduced, compared to steroid-only treatment. There were no differences found when comparing PFS between immunosuppressants. Limitations to this study include the fact that information regarding which immunosuppressant was provided to specific irAEs was absent from the data. Additionally, information about immunosuppressant dose and duration was not available from the data, suggesting that a causal association cannot be inferred between outcome and immunosuppressants. Overall, the results from this study revealed that patients receiving only steroids for irAEs fared better than those who received steroids plus other immunosuppressant therapeutic treatment.

Click to read the study in JAMA Oncology

Relevant Reading: TNF in the era of immune checkpoint inhibitors: friend or foe?

RELATED REPORTS

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

BRAFV600-mutant ctDNA as a Prognostic Biomarker in Resected Stage III Melanoma

Nivolumab plus ipilimumab improves progression-free survival in metastatic colorectal cancer

In-Depth [retrospective cohort]: This study utilized a database to enroll 385 patients who had received ipilimumab-nivolumab treatment for advanced and unresectable cutaneous melanoma and stratified them based on how their AEs were managed (steroids only vs. steroids with 2nd-line immunosuppressants (either anti-TNF or other). The most frequently noted AEs were colitis (146 patients) and hepatitis (139 patients). Median OS was longer in patients who received only steroids (46.1 months (95% CI, 39.0-not reached (NR)) as compared with those on steroids and immunosuppressant (22.5 months 95% CI, 36.5 months-NR; HR, 1.64; 95% CI, 1.16-2.32). This remained true when comparing to anti-TNF immunosuppressants as well (28.7 months, 95% CI, 12.2 months-NR; HR, 1.62; 95% CI, 1.07-2.46), but not when comparing to other immunosuppressants (22.4 months; 95% CI, 13.2 months-NR; HR, 1.59; 95% CI, 0.95-2.65). The median PFS was longer for patients receiving only steroids for management of their AEs (11.3 months, 95% confidence interval (CI), 9.6-19.5 months) as compared to those receiving steroids and either second-line immunosuppressant (5.4 months, 95% CI, 4.5-12.4 months; hazard ratio (HR), 1.43; 95% CI, 1.07-1.90). Similarly, patients on steroid plus anti-TNF or other immunosuppressant had shorter median PFS (5.4 months (95% CI, 4.7-13.1 months) and 4.3 months (95% CI, 2.5-13.2 months), respectively). There was no significant difference in PFS between immunosuppressant groups.

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: #anti-TNFaAnti-TNFimmune checkpointimmune checkpoint inhibitor adverse eventsimmune checkpoint inhibitorsimmune-related adverse eventsimmunosuppressantimmunosuppressive therapyipilimumabirAEsmelanomaNivolumabnivolumab-ipilimumabskinsteroids
Previous Post

Patient specific instrumentation associated with less operating time for total knee arthroplasties

Next Post

Wellness Check: Sleep

RelatedReports

Prognostic indicators for transarterial chemoembolization in patients with hepatocellular carcinoma with extrahepatic spread identified
AI Roundup

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

June 12, 2025
Significant reduction in prostate screening rates after revised guidelines
Chronic Disease

BRAFV600-mutant ctDNA as a Prognostic Biomarker in Resected Stage III Melanoma

April 28, 2025
Development of a risk index for colorectal cancer screening
Chronic Disease

Nivolumab plus ipilimumab improves progression-free survival in metastatic colorectal cancer

April 3, 2025
“No Evidence of Disease Activity” may be useful goal in multiple sclerosis
Chronic Disease

Ipilimumab/Nivolumab versus Nivolumab in Melanoma Brain Metastases

February 24, 2025
Next Post
Plagiocephaly/brachycephaly associated with lower cognitive and academic achievement scores

Wellness Check: Sleep

Parents often unaware of adolescents’ suicidal thoughts

Single dose of psilocybin decreases depression scores in patients with treatment-resistant depression

Disparities in type 1 diabetes not explained by socioeconomic status alone

Low neighborhood opportunities lead to increased disease severity and hospitalizations

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Obicetrapib Reduced LDL Cholesterol in Patients at High Cardiovascular Risk
  • St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes
  • Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.