Tag: steroids

1. Among a large cohort of children in Taiwan, oral corticosteroids prescribed for <14 days were associated with an increased risk of gastrointestinal (GI) bleeds, sepsis, and pneumonia during the first month of therapy initiation. Evidence level rating: 2 (Good) Oral corticosteroids are commonly prescribed to children for various...
1. Among a large cohort of Danish adults, the use of potent or very potent topical corticosteroids was found to be associated with an increased risk of osteoporosis and major osteoporotic fracture. Evidence Level Rating: 2 (Good) It is well established that in their systemic and inhaled forms, corticosteroids have a...
1. In a study of children with pneumonia or sinusitis, opioids and corticosteroids were inappropriately prescribed more frequently in the emergency department (ED) for both conditions compared to the ambulatory setting. 2. Overall, 1 in 16 children with pneumonia and 1 in 13 children with sinusitis were prescribed an opioid...
1. Patients experienced a greater incidence of severe adverse events during the 3-month period following prescription of a steroid burst compared to the 3-month period prior. 2. During the posttreatment period, the risk for severe adverse events generally appeared to decrease over time but nonetheless remained elevated above baseline. Evidence Rating...
1. In a study of children with pneumonia or sinusitis, opioids and corticosteroids were inappropriately prescribed more frequently in the emergency department (ED) for both conditions compared to the ambulatory setting. 2. Overall, 1 in 16 children with pneumonia and 1 in 13 children with sinusitis were prescribed an opioid...
Epidemiology, Clinical Course, and Outcomes of Critically Ill Adults With COVID-19 In New York City: A Prospective Cohort Study 1. COVID-19-positive adults were commonly found to have at least one comorbid condition, including hypertension and diabetes. 2. In-hospital mortality was independently associated with older age, chronic cardiac and pulmonary diseases, and...
1. Immune-related adverse events are associated with a longer recurrence-free survival in patients with stage III melanoma treated with pembrolizumab. Evidence Rating Level: 1 (Excellent) Immune-related adverse events (irAEs) occur frequently in patients treated with immune checkpoint inhibitors (ICIs). Retrospective studies and small prospective studies have reported an association between irAEs and...
1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure and bilateral pulmonary infiltrates, is associated with significant mortality rates and currently have...
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial 1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure...
1. Immune-related adverse events are associated with a longer recurrence-free survival in patients with stage III melanoma treated with pembrolizumab. Evidence Rating Level: 1 (Excellent) Immune-related adverse events (irAEs) occur frequently in patients treated with immune checkpoint inhibitors (ICIs). Retrospective studies and small prospective studies have reported an association between irAEs and...