• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Emergency

Albuterol-budesonide combination efficacious for asthma exacerbation rescue

byNhat Hung (Benjamin) LamandKiera Liblik
June 21, 2022
in Emergency, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. A high-dose combination inhaler of albuterol and budesonide was superior to albuterol alone in reducing the risk of severe asthma exacerbation.

2. Albuterol-budesonide combination had a similar safety profile to albuterol-alone treatment.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Asthma is a chronic disease that involves airway hypersensitivity, inflammation, and obstruction. Glucocorticoids, such as budesonide, serve as maintenance therapy. Though, patients experiencing loss of asthma control also rely on albuterol and other short-acting β2-agonists (SABAs) for rescue. It is of concern that in uncontrolled asthma rescue SABA alone does not address underlying inflammation and carries a risk of severe exacerbation. Fixed-dose combinations of glucocorticoid and SABA are being explored as alternative rescue therapies for this population. The present study compared the efficacy of fixed-dose combination regimens of budesonide at high and low doses with albuterol against albuterol alone in preventing severe asthma exacerbation in high-risk patients. Patients continued to receive glucocorticoid-containing maintenance therapy throughout the trial. It was found that the combination of albuterol and high-dose budesonide resulted in a significantly lower risk of severe exacerbation compared to albuterol alone. The incidence of adverse events was similar across groups. Although children only comprised a minority in this trial where statistical significance was lacking, the results provided evidence to support the use of budesonide-albuterol combination as rescue therapy for asthma patients at risk of severe exacerbation.

Click here to read the study in NEJM

Relevant Reading: Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma

In-Depth [randomized control trial]: The present double-blind randomized control trial compared the efficacy of albuterol-budesonide combinations against albuterol alone as rescue therapy for patients with poorly controlled high-risk asthma. Patients four years and older with symptomatic asthma who had had at least one severe exacerbation in the previous 12 months were recruited. Patients were randomized in a 1:1:1 ratio to one of three inhaler regimens: a higher-dose combination of 180µg albuterol and 160µg budesonide, a lower-dose combination of 180µg albuterol and 80µg budesonide, or 180µg albuterol alone. The primary efficacy endpoint was the time to first event of severe asthma exacerbation. Secondary efficacy endpoints included annualized rate of exacerbations, total systemic glucocorticoid need, and quality of life questionnaires at week 24. The risk of severe asthma exacerbation was 26% lower in the high-dose combination group than albuterol-alone (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.62 to 0.89; p=0.001). The HR in the lower-dose combination against albuterol-alone was 0.84 (95% CI, 0.71 to 1.00; p=0.052). The annualized rate of severe exacerbations was 0.43 (95% CI, 0.33 to 0.58) for the high-dose combination and 0.58 (95% CI, 0.44 to 0.77) for albuterol-alone (rate ratio (RR), 0.75; 95% CI, 0.61 to 0.91). The annualized rate of severe exacerbations was 0.48 (95% CI, 0.37 to 0.63) for lower-dose combination and 0.60 (95% CI, 0.46 to .079) for albuterol alone (RR, 0.81; 95% CI, 0.66 to 0.98). The higher-dose combination was also associated with improvements in quality of life. Adverse event rates were similar across the three groups. Overall, the study results added to the current body of evidence supporting the combination of glucocorticoids and β2-agonists as rescue therapy to reduce the risk of severe exacerbations in patients with poorly controlled asthma.

RELATED REPORTS

72- and 36-hour fever prevention post-cardiac arrest equivalent in preventing mortality

Over-the-scope clips superior to standard treatment of nonvariceal upper GI bleeding

Early restrictive fluid management does not reduce mortality in sepsis-induced hypotension

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: albuterolasthmabudesonideemergencypulmonary
Previous Post

The Moderna mRNA vaccine prevents COVID-19 infection in adolescents

Next Post

Meaning-centered play may increase spiritual sensitivity of children

RelatedReports

Cardiac mortality paradoxically lower during times of national cardiology conferences
Cardiology

72- and 36-hour fever prevention post-cardiac arrest equivalent in preventing mortality

March 24, 2023
Gastric bypass surgery reduces cardio-metabolic risk factors
Emergency

Over-the-scope clips superior to standard treatment of nonvariceal upper GI bleeding

March 22, 2023
Hypotonic IVF linked to increased risk of hyponatremia
Chronic Disease

Early restrictive fluid management does not reduce mortality in sepsis-induced hypotension

February 17, 2023
Palliative chemotherapy associated with more ICU treatment at end-of-life
Emergency

Pegylated interferon lambda reduces the risk of COVID-19-related hospitalization

February 17, 2023
Next Post
Adolescent mothers in protective care more likely to have their children placed in care

Meaning-centered play may increase spiritual sensitivity of children

Quick Take: Impact of scribes on emergency medicine doctors’ productivity and patient throughput: multicentre randomised trial

Social risk factors associated with increased pediatric emergency department utilization

The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

ANNEXA-A and ANNEXA-R trials: Andaxanet Alfa for Reversal of Apixaban and Rivaroxaban [Classics Series]

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Abnormal menstruation may be associated with worse cardiometabolic outcomes later in life
  • Past infection with pre-omicron variants of COVID-19 protects against re-infection
  • No difference in complete expulsion of intrauterine device between early and standard interval postpartum placement
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options