• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Endocrinology

Artificial pancreas may decrease hypoglycemic episodes in type I diabetic children

byDeepti Shroff KarhadeandDavid Wang
June 11, 2016
in Endocrinology, Pediatrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a randomized, crossover trial of continuous closed-loop insulin delivery program (artificial pancreas) versus a traditional sensor-guided pump in type I diabetic (T1DM) children, the artificial pancreas demonstrated lower rates of overnight time-in-hypoglycemia

2. There was a significant increase in mean glucose levels in the artificial pancreas group

Evidence Rating Level: 1 (Excellent)      

Study Rundown: Artificial pancreas refers to a continuous, automated, closed-loop glucose monitoring and insulin delivery program that provides a novel new method for glycemic control in patients with T1DM. Although previous studies have demonstrated improved efficacy of the artificial pancreas in adults and adolescents, there has been a paucity of data in children. The purpose of this randomized, cross-over trial was to elucidate the effectiveness of the artificial pancreas in outpatient children.

This trial enrolled 30 T1DM children, aged 5 to 9 years old, to a 6-day cross-over trial of both the artificial pancreas as well as the traditional parent-managed, sensory-augmented pump (SAP). At the conclusion of the study, there was a significant reduction in the overnight hypoglycemia duration in the artificial pancreas group compared to SAP. Additionally, there was no significant change with the overall time within glycemic target between both groups. The artificial pancreas group did demonstrate a significantly higher mean serum glucose level compared to SAP. The results of this trial highlight a potential benefit on artificial pancreas in providing robust glycemic control in children. This was the first study to determine the efficacy of the artificial pancreas in this patient population in an outpatient setting. Additional longer trials are warranted to confirm the efficacy of the artificial pancreas in the real-world setting. Additionally, the current study used an insulin delivery algorithm developed in adults; a modified algorithm for children may further improve the side effect profile, including a reduction in the mean serum glucose levels for children who use an artificial pancreas.

Click to read the study in Diabetes Care

RELATED REPORTS

No Content Available

Relevant Reading: Closed-loop insulin therapy improves glycemic control in children aged <7 years: a randomized controlled trial

In-Depth [randomized controlled trial]: The Pediatric Artificial Pancreas (PedArPan) is an open-labeled, randomized, cross-over trial of artificial pancreas versus SAP in the pediatric outpatient population from 5 pediatric centers in Italy. The cross-over trial occurred over six days in an outpatient camp setting. The key inclusion criteria included children aged 5 to 9 with a diagnosis of T1DM, use of insulin pump and sensor >3 months, and HbA1c <10%. Children were provided the randomized to either artificial pancreas or SAP and cross-over in three days after a 24-hour washout period. Structured diet and exercise programs were maintained in the camp settings for both interventions. The primary outcomes of glucose control was the percentage of time spent in the target glycemic range and the percent of time spent below 70mg/dL (time-in-hypoglycemia). Overall, 30 children (19 boys, 11 girls; average age: 7.6 years) were included in the study. At the conclusion of the study, there was a significant reduction in overnight time-in-hypoglycemia in the artificial pancreas group compared to SAP (0.0% vs. 2.2%; p = 0.002) without a reduction in the time spent in target glycemic range (56.0% vs. 59.7%; p = 0.430). The artificial pancreas group did demonstrate significant higher mean glucose levels compared to SAP during the study (169 mg/dL versus 147mg/dL; p < 0.001).

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

Tags: artifical pancreastype 1 diab
Previous Post

Indacaterol/glycopyrronium superior to salmeterol/fluticasone in reducing annual COPD exacerbations: The FLAME Study

Next Post

Robotic surgery faster with similar outcomes for endometrial cancer

RelatedReports

No Content Available
Next Post
Needlestick injuries most common in first six months of residency

Robotic surgery faster with similar outcomes for endometrial cancer

E-cigarette use may increase risk of smoking cigarettes in teens

Nanoliposome allows for targeted drug delivery to treat pancreatic cancer [PreClinical]

Dual-function nanoparticles deliver anti-tumor compounds and track treatment efficacy  [PreClinical]

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Mazdutide significantly reduces weight in adults with overweight or obesity
  • Oral vancomycin may be effective for pouchitis in inflammatory bowel disease
  • Inebilizumab improves outcome in patients generalized myasthenia gravis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.