Ciprofloxacin is non-inferior to aminoglycoside-ciprofloxacin for bubonic plague treatment
1. In this randomized controlled trial, among patients with bubonic plague, oral ciprofloxacin monotherapy was found to be noninferior to...
Finerenone with empagliflozin beneficial for managing CKD and type 2 diabetes
1. Among patients with both chronic kidney disease (CKD) and type 2 diabetes (T2D) already on a renin-angiotensin system (RAS)...
Trastuzumab deruxtecan leads to longer overall survival than ramucirumab plus paclitaxel in HER2-positive gastric cancer
1. In this randomized controlled trial, among adults with HER2-positive unresectable or metastatic gastric cancer who had previously progressed on...
Australian couple-based genetic screening program feasible and accepted
1. In this prospective cohort study, genetic screening among Australian reproductive couples was widely accepted and associated with low decisional...
Weekly basal insulin efsitora effective for managing type 2 diabetes
1. In patients with type 2 diabetes mellitus (T2DM) who had not previously been on insulin therapy, once-weekly fixed-dose insulin...
Tirzepatide leads to greater weight loss than semaglutide among adults with obesity
1. In this randomized controlled trial, among adults with obesity, it was found that tirzepatide resulted in a significantly greater...
Inavolisib lengthens progression-free survival time in HER2-negative advanced breast cancer
1. In this randomized controlled trial, in patients with PIK3CA-mutated advanced breast cancer, the addition of inavolisib to a palbociclib-fulvestrant...
Pembrolizumab improves survival in locally advanced head and neck cancer
1. Among patients with locally advanced head and neck squamous-cell carcinoma (HNSCC), neoadjuvant and adjuvant pembrolizumab improved event-free survival compared...
Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis
1. In this randomized trial, among patients with idiopathic pulmonary fibrosis (IPF), nerandomilast slowed the decline in the forced vital...
Mazdutide significantly reduces weight in adults with overweight or obesity
1. In this randomized controlled trial, weekly administration of Mazdutide resulted in significant weight reduction in adults classified as overweight...
