Oral sebetralstat provides early symptom relief for hereditary angioedema attacks
1. In this randomized controlled trial, oral sebetralstat provided faster times to the beginning of symptom relief than placebo in...
Preoxygenation with noninvasive ventilation reduces hypoxemia during intubation
1. In this randomized controlled trial involving critically ill adults undergoing tracheal intubation, those who were preoxygenated with bilevel-positive airway...
SARS-CoV-2 vaccination side effects associated with increased neutralizing antibodies
1. In a prospective cohort study of individuals vaccinated against SARS-CoV-2, symptomatic patients had higher levels of neutralizing antibodies (nAB)...
Brigatinib decreases the size of NF2-related progressive tumors
1. In this randomized controlled trial, brigatinib reduced the size of progressively growing tumors in patients with neurofibromatosis type 2-related...
Anti-CD38 monoclonal antibody improves platelet counts in immune thrombocytopenia
1. In this randomized controlled trial, CM313, an anti-CD38 monoclonal antibody therapy, was associated with rapid recovery of platelet counts...
APOE3 Christchurch heterozygosity may delay cognitive impairment in Alzheimer’s disease
1. Carriers of the E280A variant of presenilin 1 (PSEN1E280A) who were heterozygous for the apolipoprotein E3 Christchurch variant (APOE3Ch)...
Heat exposure associated with increased myocardial blood flow
1. In this randomized controlled trial, exposure to heat that increased core temperature by 1.5C in healthy participants was associated...
Early asthma and COPD intervention decreases healthcare utilization
1. In this randomized controlled trial, adults with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) who received pulmonologist-directed treatment...
Gene editing improves photoreceptor function in CEP290-associated retinal degeneration
1. In this randomized controlled trial, among patients with centrosomal protein 290 (CEP290)-associated retinal degeneration, subretinal injection of EDIT-101 resulted...
bpMRI associated with higher false positive rate than PSA for prostate cancer screening
1. In this decision model analysis, biparametric MRI (bpMRI) testing led to an increased rate of overdiagnosis and false positives...
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