Second-line TAF-based ART improves viral suppression in pediatric HIV
1. In this randomized controlled trial (CHAPAS-4), tenofovir alafenamide fumarate (TAF) with emtricitabine showed superior viral suppression at 96 weeks...
Oveporexton improves symptoms in patients with narcolepsy type 1
1. In this randomized controlled trial, oveporexton use significantly improved symptoms of narcolepsy over eight weeks. 2. Adverse events were...
Arsa-cel preserves motor and cognitive function in metachromatic leukodystrophy
1. In this prospective cohort study, treatment with atidarsagene autotemce (arsa-cel) significantly reduced the risk of severe motor impairment and death...
Hereditary erythrocytosis is associated with a fetal-like EPO isoform
1. This case series identified three non-coding erythropoietin (EPO) variants that significantly increased gene expression under hypoxic conditions. 2. The...
Tolebrutinib not superior to teriflunomide in reducing relapsing multiple sclerosis relapse rates
1. In concurrent randomized controlled trials (GEMINI 1 and GEMINI 2) of patients with relapsing multiple sclerosis (RMS), tolebrutinib did...
Delayed alteplase has clinical benefits in posterior circulation stroke outcomes
1. In this randomized controlled trial of patients with posterior circulation stroke not for thrombectomy, treatment with alteplase 4.5 to...
Tolebrutinib reduces disability progression in nonrelapsing secondary progressive multiple sclerosis
1. In this randomized controlled trial of patients with nonrelapsing secondary progressive multiple sclerosis (SPMS), oral tolebrutinib reduced the risk...
Pulsed field ablation noninferior to cryoablation for reducing paroxysmal atrial fibrillation recurrence
1. In this randomized controlled trial of patients with symptomatic paroxysmal atrial fibrillation, pulsed field ablation (PFA) was noninferior to...
Lepodisiran, a long-duration small interfering RNA, reduces lipoprotein(a) levels
1. Lepodisiran, a long-duration small interfering RNA targeting lipoprotein(a) synthesis, reduced serum concentrations of lipoprotein(a) compared to placebo in adults...
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF
1. In this randomized controlled trial, among men and gender-diverse persons who have sex with men, it was found that...
