Obicetrapib and ezetimibe combination therapy lowers LDL cholesterol in high-risk patients
1. FDC obicetrapib plus ezetimibe significantly decreased LDL cholesterol levels by 48.6% compared to placebo. 2. Serious adverse events were...
Chronic Disease
Reports of high-impact chronic disease studies by medical professionals
Rectoscopy alone may be sufficient to evaluate for remission of ulcerative colitis
1. Rectoscopy alone for evaluation of endoscopic and histologic remission of ulcerative colitis (UC) had good accuracy and is sufficient...
Upadacitinib with glucocorticoids superior to glucocorticoids alone for giant cell arteritis remission
1. In this randomized trial, upadacitinib dosed at 15mg with a 26-week glucocorticoid taper showed superior efficacy than placebo with...
Sotatercept reduces adverse event risk in high-risk pulmonary arterial hypertension
1. In this randomized controlled trial of patients with pulmonary arterial hypertension (PAH) and high risk of mortality, sotatercept reduced...
Oral semaglutide reduces cardiovascular event rates in high-risk patients
1. In this randomized controlled trial, oral semaglutide significantly reduced the risk of adverse cardiovascular events in patients with type...
Impaired lipoprotein cholesterol ratio is associated with cognitive impairment in patients with stroke
1. Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) was independently associated with early cognitive impairment in patients with...
Hypotension- and hypertension-avoidance strategies may yield similar neurocognitive outcomes following noncardiac surgery
1. In this randomized controlled trial, hypotension- and hypertension-avoidance strategies yielded similar post-operative delirium frequency and severity following non-cardiac surgery....
Midlife weight loss is associated with decreased risk of mortality and chronic disease
1. Participants with sustained midlife weight loss from nonsurgical and nonpharmacological intervention had a decreased risk of chronic diseases beyond...
Oveporexton improves symptoms in patients with narcolepsy type 1
1. In this randomized controlled trial, oveporexton use significantly improved symptoms of narcolepsy over eight weeks. 2. Adverse events were...
Arsa-cel preserves motor and cognitive function in metachromatic leukodystrophy
1. In this prospective cohort study, treatment with atidarsagene autotemce (arsa-cel) significantly reduced the risk of severe motor impairment and death...