Oral vancomycin may be effective for pouchitis in inflammatory bowel disease
1. In patients with pouchitis associated with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC), the use of oral...
Infectious Disease
Reports of high-impact infectious disease studies by medical professionals
Fecal microbiota transplantation may be more effective than vancomycin in treating primary C. difficile infection
1. In this randomized controlled trial, a higher proportion of patients who underwent fecal microbiota transplantation achieved clinical cure of...
Anal cancer screening cost-effective for men who have sex with men with human immunodeficiency virus aged above 35 years
1. In this microsimulation model, initiation of anal cancer screening in men who have sex with men with human immunodeficiency...
Trimethoprim-sulfamethoxazole during pregnancy does not reduce risk of prematurity
1. In this randomized controlled trial, prophylactic treatment with trimethoprim-sulfamethoxazole (TMP-SMX) was not associated with a reduction in the incidence...
Second-line TAF-based ART improves viral suppression in pediatric HIV
1. In this randomized controlled trial (CHAPAS-4), tenofovir alafenamide fumarate (TAF) with emtricitabine showed superior viral suppression at 96 weeks...
Oral gepotidacin is non-inferior to standard therapy for uncomplicated urogenital gonorrhea
1. Gepotidacin was non-inferior to ceftriaxone plus azithromycin for the primary outcome of microbiological success. 2. There were no serious...
Worsening kidney function observed following SARS-CoV-2 infection in children
1. In this cohort of children and adolescents, there was an association between SARS-CoV-2 infection and an increased risk of...
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF
1. In this randomized controlled trial, among men and gender-diverse persons who have sex with men, it was found that...
Mepolizumab decreases exacerbations in patients with eosinophilic COPD
1. In this randomized controlled trial, mepolizumab decreased the annualized rate of moderate or severe exacerbations when added to triple...
Single-dose baloxavir linked to reduced influenza transmission
1. In this randomized controlled trial, influenza-positive patients who received a single dose of baloxavir had a 29% lower adjusted...