All-oral chemotherapy regimen tolerable and efficacious for newly diagnosed acute myeloid leukemia
1. In this phase 1-2 trial involving patients with newly diagnosed acute myeloid leukemia who were ineligible for intensive chemotherapy,...
Pharma
Enzalutamide (Xtandi) and abiraterone (Zytiga) may have similar effectiveness in metastatic castration-sensitive prostate cancer
1. The use of enzalutamide (Xtandi) and abiraterone (Zytiga) in metastatic castration-sensitive prostate cancer (mCSPC) was associated with similar overall...
Intermittent metformin (Glucophage) is non-inferior to continuous metformin for prediabetes in post-partum women with prior gestational diabetes mellitus
1. Among women with prediabetes following prior gestational diabetes mellitus (GDM), intermittent metformin (Glucophage) in combination with lifestyle modifications was...
Erector spinae plane blocks may not provide meaningful benefit over standard analgesia in breast surgery patients
1. Erector spinae plane blocks reduced PACU opioid requirements and modestly shortened PACU stay, but did not produce a clinically...
Chemotherapy exposure is independently associated with reduced pain severity in advanced pancreatic cancer
1. Chemotherapy appears to be independently associated with reduced pain severity in advanced pancreatic cancer, reinforcing the importance of routine,...
Foundayo (Orforglipron) Approval Marks the Beginning of the Oral GLP-1 Era for Obesity Treatment
1. The FDA approved orforglipron (Foundayo) on April 1, 2026, making it the first non-peptide oral GLP-1 receptor agonist cleared...
Infection risk with infliximab (Remicade) and adalimumab (Humira) is similar in pediatric inflammatory bowel disease
1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating...
Letrozole (Femara) improves sperm concentration in men with spermatogenic failure
1. In adult male patients with spermatogenic failure (SPGF), letrozole (Femara) is well tolerated and associated with significantly greater upgrade rates...
The addition of leflunomide (Arava) to prednisone (Deltasone) may not improve rate of remission in Takayasu arteritis
1. Leflunomide (LEF) plus prednisone was well tolerated but did not significantly increase clinical remission of Takayasu arteritis (TAK) compared...
Perioperative vitamin C supplementation may not reduce bleeding in percutaneous renal biopsy patients
1. Administration of perioperative intravenous vitamin C for percutaneous renal biopsy may not reduce the rate of bleeding complications. Evidence...
