Axatilimab reduces symptoms in patients with graft versus host disease
1. In this randomized controlled trial, axatilimab effectively managed symptoms in patients with recurrent or refractory graft versus host disease...
Rheumatology
Quantitative sensory testing not reliable as a means for characterizing chronic pain syndromes
1. Chronic pain syndromes including fibromyalgia, dry eye disease, and irritable bowel syndrome showed no significant association with quantitative sensory...
Bimekizumab safe and effective for treatment of moderate-to-severe hidradenitis suppurative
1. Significantly more patients in the bimekizumab group than placebo reported improved clinical response at week 16. 2. Treatment-related adverse...
Resistance training not superior to neuromuscular exercises for hip osteoarthritis
1. In this randomized controlled trial, progressive resistance training (PRT) was not superior to neuromuscular exercise (NEMEX) in improving functional...
Interleukin-23 receptor antagonist improves psoriasis symptoms
1. In this randomized controlled trial, treatment with JNJ-77242113 improved psoriasis symptoms as compared to a placebo. 2. JNJ-77242113 showed...
KLKB1 gene editing therapy reduces kallikrein levels in hereditary angioedema
1. In this randomized controlled trial, gene-editing therapy targeting the kallikrein B1 gene (KLKB1) led to a significant reduction in...
Methotrexate alleviates pain among patients with hand osteoarthritis and concurrent synovitis
1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype....
Anxiety may be linked to C3 and C4 levels in patients with systemic lupus erythematosus
1. In this cross-sectional study, there was a significant negative correlation between anxiety scores and C3 levels in patients with...
Sarilumab increases remission rate in patients with polymyalgia rheumatica relapse
1. In this randomized controlled trial, patients with polymyalgia rheumatica (PMR) flares who received sarilumab with a prednisone taper demonstrated...
Spesolimab may improve quality of life in patients with generalized pustular psoriasis flares
1. Efficacy of spesolimab appeared to be dose-dependent with high-dose spesolimab leading to a significantly longer time to GPP flare-up...