Zidovudine reduces maternal-infant HIV transmission [Classics Series]
1. Among pregnant women with HIV, antepartum, intrapartum and neonatal zidovudine therapy reduced maternal-fetal transmission of HIV by two-thirds. Original...
General Medicine Classics
Physician-written reports of landmark medical studies
The ORACLE trial: Antibiotics for preterm, prelabor rupture of membranes [Classics Series]
1. Among infants born to women with preterm, premature rupture of membranes, those whose mothers were randomized to treatment with...
The PROSEVA trial: Proning in severe ARDS [Classics Series]
1. In patients with severe acute respiratory distress syndrome (ARDS), prone-positioning significantly reduced 28-day and 90-day mortality when compared with...
The ACURASYS trial: Neuromuscular blockade in early ARDS [Classics Series]
1. In patients with severe acute respiratory distress syndrome (ARDS), treatment with neuromuscular blockade in the first 48 hours significantly...
Omeprazole versus placebo for bleeding peptic ulcer [Classics Series]
1. Patients presenting with upper gastrointestinal bleeds experienced significantly lower risk of continued bleeding and need for surgery to control...
Omeprazole before endoscopy in patients with gastrointestinal bleeding [Classics Series]
1. Compared to placebo, treating patients with omeprazole bolus and infusion prior to endoscopy significantly reduces the need for endoscopic...
Diffusion-weighted MRI highly sensitive, specific vs. CT in acute ischemic stroke [Classics Series]
1. Among patients with acute neurologic deficits presenting within six hours of symptoms onset, diffusion-weight magnetic resonance imaging (DWI) was...
The V-HeFT I: Hydralazine and isosorbide dinitrate in heart failure [Classics Series]
1. In patients with congestive heart failure, the combination of hydralazine and isosorbide dinitrate significantly reduced mortality when compared with...
The CNTG trial: Intra-ocular pressure reduction slows progression of normal-tension glaucoma [Classics Series]
1. Reduction of intra-ocular pressure (IOP) with topical medications in normal-tension glaucoma significantly reduced risk of progression to visual field...
The CATT study: Avastin and Lucentis equally effective for macular degeneration [Classics Series]
1. Lucentis (ranibizumab) and Avastin (bevaciumab) demonstrated equivalent effects on visual acuity in age-related macular degeneration (AMD) patients after 1 year...
