• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home The Classics Emergency Classics

Omeprazole versus placebo for bleeding peptic ulcer [Classics Series]

byAndrew Cheung, MD MBA
March 12, 2015
in Emergency Classics, General Medicine Classics, Surgery Classics, The Classics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Patients presenting with upper gastrointestinal bleeds experienced significantly lower risk of continued bleeding and need for surgery to control bleeding when treated with omeprazole as compared with placebo.

2. There was no significant difference in mortality between the two groups, though the omeprazole group had significantly lower red cell transfusion requirements.

Original Date of Publication: April 1997

Study Rundown: Upper gastrointestinal bleeding is a common cause of hospitalization. While endoscopy has long been an important component of managing upper gastrointestinal bleeds, there were no well-studied medical therapies at the time this trial was conducted. It had been shown that platelet function is poorer in low pH, thus, it was thought that reducing gastric acidity would help control bleeding. Prior studies with H2-receptor antagonists demonstrated mixed results, as intravenous famotidine was not shown to be effective. The purpose of this trial was to explore whether treatment with a proton pump inhibitor would improve mortality and need for surgery in patients presenting with upper gastrointestinal bleeds. In summary, patients treated with omeprazole had significantly lower rates of continued bleeding and surgery for ongoing bleeding compared to those being treated with placebo. There was no significant difference between the two groups in bleeding-related mortality 30 days after admission.

Click to read study in NEJM

In-Depth [randomized controlled trial]: This trial was conducted at a single tertiary care centre in India. A total of 220 patients were randomized to either treatment with oral omeprazole 40 mg Q12H for 5 days of matching placebo. After appropriate resuscitation, all patients underwent upper endoscopy within 12 hours after admission. Patients with duodenal, gastric or stomal ulcers and stigmata of recent hemorrhage (i.e., arterial spurting, visible vessel, oozing from ulcer, adherent clot to ulcer) were considered eligible for the trial. Exclusion criteria were severe terminal illness that made endoscopy dangerous or undesirable, profuse hemorrhage with persistent shock necessitating emergent surgical intervention, or bleeding from a Mallory-Weiss tear/varices/erosion/tumours/unknown source. Endpoints studied were continued bleeding, recurrent bleeding, surgery, and mortality within 30 days after admission from causes related to bleeding or treatment.

RELATED REPORTS

Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]

Omeprazole before endoscopy in patients with gastrointestinal bleeding [Classics Series]

Proton pump inhibitor boluses as effective as infusions in ulcer bleeds

The risk of continued bleeding was significantly higher in the placebo group compared to the omeprazole group (OR 4.7; 95%CI 2.7-7.4). The risk of surgery to control bleeding was also significantly higher in the placebo group (OR 3.9; 95%CI 1.7-8.5). There was no significant difference between the two groups in terms of the risk of mortality. Patients in the omeprazole group required significantly fewer units of blood transfused per patient (p<0.001).

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. No article should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2 Minute Medicine, Inc.

Tags: gastrointestinal haemorrhageomeprazole
Previous Post

Surgical vs. non-surgical treatment of humeral fractures similar in outcome

Next Post

Adding bevacizumab may not improve breast cancer survival

RelatedReports

Adverse pregnancy outcomes associated with thrombophilias [Classics Series]
Emergency Classics

Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]

November 4, 2015
Classics Series, Landmark Trials in Medicine
General Medicine Classics

Omeprazole before endoscopy in patients with gastrointestinal bleeding [Classics Series]

April 19, 2015
Proton pump inhibitor boluses as effective as infusions in ulcer bleeds
Chronic Disease

Proton pump inhibitor boluses as effective as infusions in ulcer bleeds

September 8, 2014
Emergency Classics

The Rockall score: Risk assessment after acute upper gastrointestinal haemorrhage [Classics Series]

October 22, 2013
Next Post
Adjuvant radiation decreases local recurrence in low-risk breast cancer

Adding bevacizumab may not improve breast cancer survival

Long-term active surveillance may be safe in low-risk prostate cancer

Decision aids maybe be underutilized in treating prostate cancer

Stepped-care management useful for chronic pain treatment in veterans (ESCAPE Trial)

Stepped-care management useful for chronic pain treatment in veterans (ESCAPE Trial)

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.