General Medicine Classics

Physician-written reports of landmark medical studies

The RECIST 1.1 trial: Measuring tumor burden to assess response to therapy [Classics Series]

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies,...
Classics Series, Landmark Trials in Medicine

Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]

1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...

The PARADIGM-HF trial: Valsartan-neprilysin inhibitor vs. enalapril in patients with heart failure [Classic Series]

1. LCZ696, a combination of valsartan with a neprilysin inhibitor, significantly reduced the risk of death from cardiovascular causes and hospitalization due to heart...

The DOSE trial: Loop diuretic strategies in acute decompensated heart failure [Classics Series]

1. The use of loop diuretics in acute decompensated heart failure is commonplace, but clinical practice varies widely with regards to the dosage and...

The AREDS2: No benefit from additional carotenoid and omega-3-fatty acid supplementation to original AREDS...

1. There was no added benefit observed with adding lutein and zeaxanthin, omega-3-fatty acids (DHA and EPA), or the combination to the original AREDS...

The EVS: Vitrectomy results in better visual outcomes for light-perception patients [Classics Series]

1. In patients with endophthalmitis after recent lens implantation, immediate vitrectomy significantly improved visual outcomes for patients presenting with light-perception visual acuity compared to...

The TNT trial: Intensive statin therapy in coronary heart disease [Classics Series]

1. In patients with stable coronary heart disease (CHD), high-dose atorvastatin significantly reduced the risk of major cardiovascular events when compared to low-dose.2. Patients...

The ONTT: Intravenous steroids lead to faster visual recovery in optic neuritis [Classics Series]

1. In patients with first presentation of optic neuritis, treatment with intravenous methylprednisolone followed by oral prednisone resulted in faster visual recovery when compared...

The AREDS1: Zinc and antioxidant supplementation reduce progression of AMD in high-risk patients [The...

1. In patients with advanced age-related macular degeneration (AMD) in one eye only or intermediate AMD in either eye, zinc and antioxidant supplementation reduced...

The FREEDOM trial: Coronary bypass graft vs. PCI in diabetic patients [Classics Series]

1. In patients with diabetes and multivessel disease, coronary artery bypass grafting (CABG) was shown to be superior to percutaneous coronary intervention (PCI) with...
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