The POISE 2 trial: Aspirin increases risk of major bleeding after noncardiac surgery [Classic...
1. After noncardiac surgeries, patients treated with aspirin had significantly increased risk of major bleeding compared to those taking placebo.2. There was no significant...
V-HeFT II: Enalapril reduces mortality in heart failure when compared to hydralazine and isosorbide...
1. In patients with heart failure, patients treated with enalapril experienced significantly lower mortality at 2-years compared to patients on hydralazine and isosorbide dinitrate.2....
The MADIT-CRT trial: Cardiac resynchronization therapy in heart failure [Classics Series]
1. In patients with heart failure, reduced left ventricular ejection fraction, and prolonged QRS>130 ms, treatment with cardiac resynchronization therapy (CRT), in addition to...
The EMGT: Reducing intraocular pressure slows progression of glaucoma [Classics Series]
1. Treatment using laser trabeculoplasty and topical betaxolol hydrochloride to reduce intraocular pressure (IOP) is associated with delayed progression of glaucoma2. Treatment to decrease...
The RE-ALIGN trial: Dabigatran vs. warfarin for mechanical heart valves [Classics Series]
1. In patients with mechanical heart valves, anticoagulation with dabigatran was associated with significantly higher rates of stroke and major bleeding when compared to...
The CHARM-Added trial: Adding candesartan to ACE inhibitor reduces mortality in heart failure [Classics...
1. Angiotensin-converting-enzyme (ACE) inhibitors had been shown to significantly reduce mortality in patients with heart failure, and it was hypothesized that adding an angiotensin-receptor...
The SOME trial: Screening for occult malignancy in unprovoked venous thromboembolism [Classics Series]
1. Patients with a first unprovoked venous thromboembolism were randomized to either limited-screening for occult malignancy or limited-screening plus computed tomography (CT) of the...
Voriconazole superior to amphotericin B for invasive aspergillosis [Classics Series]
1. In immunocompromised patients with invasive aspergillosis, treatment with voriconazole was found to be superior to amphotericin B in achieving successful outcomes.2. The incidence...
Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]
1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved or possible infections when...
The CONSENSUS: Enalapril reduces mortality in severe heart failure [Classics Series]
1. In patients with severe heart failure, treatment with enalapril significantly reduced the risk of mortality at 6-months and 1-year when compared with placebo.2....
