![Adverse pregnancy outcomes associated with thrombophilias [Classics Series]](https://www.2minutemedicine.com/wp-content/uploads/2015/07/Classics-2-Minute-Medicine-e1436017941513-350x250.png)
The AVERROES trial: Apixaban vs aspirin in atrial fibrillation [Classics Series]
1. In patients with atrial fibrillation who were unable to receive warfarin for any reason, the use of apixaban reduced...
General Medicine Classics
Physician-written reports of landmark medical studies
The SCD-HeFT: ICD vs. amiodarone for congestive heart failure [Classics Series]
1. In patients with congestive heart failure (CHF) and reduced ejection fraction, mortality was significantly lower in patients who received...
The HOT trial: Diastolic blood pressure targets in hypertension [Classics Series]
1. In hypertensive patients, there were no significant differences between different diastolic blood pressure (dBP) targets (≤90 mmHg,≤85 mmHg,≤80 mmHg)...
Liraglutide associated with lower incidence of death from CV causes in type 2 diabetics
1. Patients with type 2 diabetes who received liraglutide were observed to have a significantly lower incidence of the composite...
The SPRINT: Intensive vs. standard blood pressure control [Classics Series]
1. In patients with hypertension and elevated cardiovascular risk, treating to a target systolic blood pressure of 120 mmHg significantly...
The BHAT: Propranolol after acute myocardial infarction [Classics Series]
1. Beta-blockers were commonly used in the treatment of coronary artery disease in the 1980s, though prior studies were inconclusive...
The REMATCH trial: Left ventricular assist devices reduce mortality in heart failure [Classics Series]
1. In patients with end-stage heart failure on optimal medical therapy, treatment with a left ventricular assist device (LVAD) significantly...
The VALIANT trial: Valsartan vs. captopril in patients with acute myocardial infarction and heart failure [Classic Series]
1. In patients with acute myocardial infarction and heart failure/evidence of left ventricular dysfunction, patients treated with valsartan and captopril...
The POISE 2 trial: Aspirin increases risk of major bleeding after noncardiac surgery [Classic Series]
1. After noncardiac surgeries, patients treated with aspirin had significantly increased risk of major bleeding compared to those taking placebo....
V-HeFT II: Enalapril reduces mortality in heart failure when compared to hydralazine and isosorbide [Classics Series]
1. In patients with heart failure, patients treated with enalapril experienced significantly lower mortality at 2-years compared to patients on...