General Medicine Classics

Physician-written reports of landmark medical studies

The SHIFT: Ivabradine in congestive heart failure [Classics Series]

1. In patients with congestive heart failure (CHF) and baseline heart rate >70 bpm, ivabradine significantly reduced the risk of heart failure hospitalization and...

The LRC-CPPT 1: Cholestyramine and coronary heart disease [Classics Series]

1. In the 1970s, observational data suggested a direct link between serum cholesterol levels and the risk of coronary heart disease (CHD).2. This trial...

The ICAP trial: Colchicine in acute pericarditis [Classics Series]

1. Colchicine has been commonly used in the treatment of inflammatory conditions, including gout and serositis.2. This study demonstrated that colchicine, in addition to...

The AVERROES trial: Apixaban vs aspirin in atrial fibrillation [Classics Series]

1. In patients with atrial fibrillation who were unable to receive warfarin for any reason, the use of apixaban reduced the risk of stroke...

The SCD-HeFT: ICD vs. amiodarone for congestive heart failure [Classics Series]

1. In patients with congestive heart failure (CHF) and reduced ejection fraction, mortality was significantly lower in patients who received an implantable cardioverter-defibrillator (ICD)...

The HOT trial: Diastolic blood pressure targets in hypertension [Classics Series]

1. In hypertensive patients, there were no significant differences between different diastolic blood pressure (dBP) targets (≤90 mmHg,≤85 mmHg,≤80 mmHg) with regards to the...

The SPRINT: Intensive vs. standard blood pressure control [Classics Series]

1. In patients with hypertension and elevated cardiovascular risk, treating to a target systolic blood pressure of 120 mmHg significantly reduced the risk of...

The BHAT: Propranolol after acute myocardial infarction [Classics Series]

1. Beta-blockers were commonly used in the treatment of coronary artery disease in the 1980s, though prior studies were inconclusive due to limitations in...

The REMATCH trial: Left ventricular assist devices reduce mortality in heart failure [Classics Series]

1. In patients with end-stage heart failure on optimal medical therapy, treatment with a left ventricular assist device (LVAD) significantly reduced the risk of...

The VALIANT trial: Valsartan vs. captopril in patients with acute myocardial infarction and heart...

1. In patients with acute myocardial infarction and heart failure/evidence of left ventricular dysfunction, patients treated with valsartan and captopril experienced similar all-cause mortality.2....
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