The DASH trial: Diet change significantly reduces blood pressure [Classics Series]
Image: PD 1. A “combination” diet rich in fruits and vegetables and low in saturated and total fat reduces blood...
General Medicine Classics
Physician-written reports of landmark medical studies
The EPHESUS trial: Eplerenone in heart failure after myocardial infarction [Classics Series]
Image: PD 1. Eplerenone significantly reduces all-cause mortality in patients with heart failure and left ventricular dysfunction (LVEF≤40%) after myocardial...
The PANTER trial: Open necrosectomy vs step-up approach for necrotizing pancreatitis [Classics Series]
Image: PD 1. A minimally invasive step-up approach significantly reduced the rate of major complications as compared to open necrosectomy...
Magnesium sulfate in torsade de pointes [Classics Series]
Image: PD 1. Intravenous magnesium sulfate was effective at acutely terminating torsade de pointes. 2. Intravenous magnesium sulfate was not...
The ATLAS trial: ACE inhibitor dosing in chronic heart failure [Classics Series]
Image: PD 1. When compared to a lower dose, high-dose angiotensin-converting-enzyme inhibitor significantly reduced the risk of hospitalization or death...
The PLCO trial 1: PSA and digital rectal examination in prostate cancer screening [Classics Series]
Image: PD 1. Subjects undergoing annual prostate-specific antigen (PSA) testing for 6 years and annual digital rectal examination (DRE) for...
Donepezil and vitamin E in Alzheimer’s disease [Classics Series]
Image: PD 1. High-dose vitamin E supplementation does not slow down progression to Alzheimer’s disease 2. Donepezil, a cholinesterase inhibitor,...
Symptom-triggered benzodiazepine treatment for alcohol withdrawal [Classics Series]
Image: PD 1. For patients withdrawing from alcohol, a symptom-triggered pharmacologic therapy may decrease detoxification time without compromising the safety...
The PLCO trial 2: Flexible sigmoidoscopy in colon cancer screening [Classics Series]
Image: PD 1. Screening with flexible sigmoidoscopy is associated with a significant decrease in colon cancer incidence in the distal...
Endoscopic biliary drainage in acute cholangitis [Classics Series]
Image: PD 1. For patients with severe acute cholangitis due to choledocholithiasis, endoscopic biliary drainage reduces hospital mortality compared to...
