The MDRD trial: Protein intake and blood pressure control in renal insufficiency [Classics Series]
1. Reducing protein intake and lower blood pressure targets did not significantly delay the rate of decline in GFR in...
General Medicine Classics
Physician-written reports of landmark medical studies
Fidaxomicin vs. vancomycin in C. difficile infection [Classics Series]
1. Fidaxomicin is non-inferior to vancomycin in achieving clinical cure of C. difficile infection 2. Fidaxomicin therapy significantly reduces the...
The TORCH trial: Combination of salmeterol and fluticasone in treating COPD [Classics Series]
1. The combination of salmeterol and fluticasone did not significantly reduce all-cause mortality in patients with chronic pulmonary obstructive disease...
The NETT: Lung-volume-reduction surgery in emphysema
Image: PD 1. Lung-volume-reduction surgery significantly improves exercise capacity, but not overall survival, in patients with emphysema when compared with...
The RENAAL Trial: Losartan in diabetic nephropathy [Classics Series]
Image: PD 1. In patients with type II diabetes and nephropathy, losartan at a dose of 50-100 mg daily significantly...
The SOLVD trial: Enalapril in heart failure with reduced ejection fraction [Classics Series]
Image: PD 1. Enalapril significantly reduced the risk of all-cause mortality in patients with congestive heart failure and reduced left...
The CHARM-Preserved trial: Candesartan in heart failure with preserved ejection fraction [Classics Series]
Image: PD 1. In patients with heart failure and preserved ejection fraction, candesartan does not significantly reduce the rate of...
The EMPHASIS-HF trial: Eplerenone in mild systolic heart failure [Classics Series]
Image: PD 1. Eplerenone significantly reduces mortality in patients suffering from heart failure with reduced systolic function (LVEF≤30%, or 30-35%...
The ATLAS trial: Duration of adjuvant tamoxifen in ER-positive breast cancer [Classics Series]
Image: PD 1. Among women with early ER-positive breast cancer, continuing adjuvant tamoxifen for 10 years versus stopping at 5...
Quadrivalent HPV vaccine in young women [Classics Series]
Image: PD 1. Prophylactic use of a quadrivalent vaccine against HPV strains 6, 11, 16, and 18 significantly reduced the...
