Obstetrics and Gynecology Classics

Classics Series, Landmark Trials in Medicine

Risks associated with a Trial of Labor after Cesarean Delivery (TOLAC) [Classics Series]

1. Uterine rupture occurs in less than 1% of women undergoing TOLAC.  2. The absolute risk of permanent neurological impairment in infants born to women...
Classics Series, Landmark Trials in Medicine

Magnesium reduces cerebral palsy in infants delivered early preterm [Classics Series]

1. Among women with imminent delivery between 24 and 31 weeks gestation, those randomized to receive magnesium sulfate experienced a decreased risk of moderate...
Classics Series, Landmark Trials in Medicine

HPV triage is optimal management for ASCUS [Classics Series]

1. A single human papillomavirus (HPV) test identified 92.4% of women diagnosed with CIN-III. 2. A strategy of HPV triage testing detected high-grade intraepithelial lesion...
Classics Series, Landmark Trials in Medicine

Letrozole superior to clomid for ovulation induction in PCOS [Classics Series]

1. Women with polycystic ovary syndrome (PCOS) randomized to receive letrozole had more live births than women randomized to clomiphene (27.5% vs. 19.1%, p=0.007). 2....
Classics Series, Landmark Trials in Medicine

Progesterone injections reduce recurrent preterm birth [Classics Series]

1. In women with a history of preterm birth, weekly progesterone injections reduced the risk of delivery prior to 37, 35, and 32 weeks...
Classics Series, Landmark Trials in Medicine

Vaginal progesterone for sonographic short cervix decreases preterm birth [Classics Series]

1. Among women with a sonographic short cervix, those randomized to receive daily vaginal progesterone were 45% less likely to experience preterm delivery prior to...
Classics Series, Landmark Trials in Medicine

The Women’s Health Initiative: Risks outweigh benefits of combination hormone replacement therapy [Classics Series]

1. Combination estrogen and progestin hormone replacement therapy (HRT) is associated with a 29% increased risk of cardiovascular disease, 110% increased risk of venous...
Classics Series, Landmark Trials in Medicine

Most ovarian cysts resolve, sonographic surveillance recommended [Classics Series]

1. The majority (>60%) of ovarian abnormalities, even complex, solid or bilateral cysts, resolved with serial ultrasounds. 2. Complex-appearing cysts resolved more quickly than simple-appearing...
Classics Series, Landmark Trials in Medicine

Nurses’ Health Study: Estrogen associated with lower cardiovascular disease risk [Classics Series]

1. Healthy postmenopausal nurses aged 30-53 years on estrogen therapy had a 44% reduced risk of major coronary disease compared to women not on...
Classics Series, Landmark Trials in Medicine

Twin vaginal delivery as safe as cesarean [Classics Series]

1. Among women with cephalic-presenting diamniotic twins at term, those randomized to planned cesarean delivery were not more likely to experience adverse neonatal outcomes...
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