Surgery Classics

Physician-written reports of landmark surgery studies

Classics Series, Landmark Trials in Medicine

Fidaxomicin vs. vancomycin in C. difficile infection [Classics Series]

1. Fidaxomicin is non-inferior to vancomycin in achieving clinical cure of C. difficile infection2. Fidaxomicin therapy significantly reduces the rate of recurrence and significantly...
Classics Series, Landmark Trials in Medicine

The NETT: Lung-volume-reduction surgery in emphysema

Image: PD1. Lung-volume-reduction surgery significantly improves exercise capacity, but not overall survival, in patients with emphysema when compared with medical therapy2. Post hoc subgroup...
Classics Series, Landmark Trials in Medicine

The ATLAS trial: Duration of adjuvant tamoxifen in ER-positive breast cancer [Classics Series]

Image: PD1. Among women with early ER-positive breast cancer, continuing adjuvant tamoxifen for 10 years versus stopping at 5 years after diagnosis significantly reduced...
Classics Series, Landmark Trials in Medicine

The PANTER trial: Open necrosectomy vs step-up approach for necrotizing pancreatitis [Classics Series]

Image: PD1. A minimally invasive step-up approach significantly reduced the rate of major complications as compared to open necrosectomy in patients with necrotizing pancreatitisOriginal...
Classics Series, Landmark Trials in Medicine

The PLCO trial 1: PSA and digital rectal examination in prostate cancer screening [Classics...

Image: PD1. Subjects undergoing annual prostate-specific antigen (PSA) testing for 6 years and annual digital rectal examination (DRE) for 4 years experienced significantly increased...

Initial trial of conservative management of splenic injury [Pediatrics Classics Series]

Image: PD1. The conservative, symptomatic management of 16 patients following assumed splenic injury from blunt abdominal trauma resulted in normalization of hemodynamic stability within...

The PLCO trial 2: Flexible sigmoidoscopy in colon cancer screening [Classics Series]

Image: PD1. Screening with flexible sigmoidoscopy is associated with a significant decrease in colon cancer incidence in the distal and proximal colon2. Screening with...

Endoscopic biliary drainage in acute cholangitis [Classics Series]

Image: PD1. For patients with severe acute cholangitis due to choledocholithiasis, endoscopic biliary drainage reduces hospital mortality compared to surgical decompression2. Endoscopic biliary drainage...
Classics Series, Landmark Trials in Medicine

The ARMA trial: Lower tidal volume ventilation in ALI/ARDS [Classics Series]

1. The trial was terminated early when the data demonstrated that lower tidal volume ventilator settings in ALI/ARDS patients led to a significant decrease...

Early TIPS in cirrhosis and variceal bleeding [Classics Series]

Image: PD1. In patients with severe liver disease and variceal bleeding, early transjugular intrahepatic portosystemic shunt (TIPS) significantly reduced the rate of treatment failure,...
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