Surgery Classics

Physician-written reports of landmark surgery studies

The WOEST trial: Double vs. triple therapy in patients requiring PCI and anticoagulation [Classics...

1. In patients requiring percutaneous coronary intervention (PCI) and long-term oral anticoagulation, treating with clopidogrel alone (i.e., double therapy) significantly reduced the risk of...
Classics Series, Landmark Trials in Medicine

Prednisolone vs placebo in severe alcoholic hepatitis [Classics Series]

1. Compared to placebo, treating patients with severe alcoholic hepatitis with 28 days of prednisolone significantly improved the short-term survival up to 6 months.2....
Classics Series, Landmark Trials in Medicine

Omeprazole versus placebo for bleeding peptic ulcer [Classics Series]

1. Patients presenting with upper gastrointestinal bleeds experienced significantly lower risk of continued bleeding and need for surgery to control bleeding when treated with...
Classics Series, Landmark Trials in Medicine

The AMPLIFY trial: Apixaban for treatment of venous thromboembolism [Classics Series]

1. Apixaban was found to be non-inferior to conventional therapy (i.e., enoxaparin followed by warfarin) in the treatment of acute venous thromboembolism.2. Major bleeding...
Classics Series, Landmark Trials in Medicine

Vena caval filters in pulmonary embolism prophylaxis [Classics Series]

Image: PD1. Permanent vena caval filter placement in addition to anticoagulant therapy helps prevent short-term occurrence of pulmonary embolism but increases the risk of...
Classics Series, Landmark Trials in Medicine

Albumin in cirrhotic patients with spontaneous bacterial peritonitis [Classics Series]

1. In cirrhotic patients with spontaneous bacterial peritonitis, albumin infusion on days 1 and 3 of treatment in addition to antibiotics significantly reduces the...
Classics Series, Landmark Trials in Medicine

Fecal transplantation in recurrent C. difficile infection [Classics Series]

1. Treating recurrent C. difficile infection with infusion of donor feces resulted in significantly higher cure rates than treating with vancomycin-alone or vancomycin with...
Classics Series, Landmark Trials in Medicine

The OHTS trial: Topical ocular hypotensive medication reduces risk of open-angle glaucoma [Classics Series]

1. At 5 years, the probability of developing open-angle glaucoma was significantly lower in the group that received topical ocular hypotensive medication compared to...
Classics Series, Landmark Trials in Medicine

The CARESS trial: Dual antiplatelet therapy superior to monotherapy in symptomatic carotid stenosis [Classics...

1. Dual antiplatelet therapy with clopidogrel and aspirin was associated with a significant reduction in microembolic events in patients with symptomatic carotid stenosis compared...
Classics Series, Landmark Trials in Medicine

Finasteride significantly reduces incidence of prostate cancer [Classics Series]

1. Finasteride therapy was found to significantly reduce the incidence of prostate cancer compared to placebo.2. Patients treated with finasteride were significantly more likely...
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