The BRIDGE trial: Periprocedural bridging in patients with atrial fibrillation [Classics Series]
1. Patients with atrial fibrillation are often treated with long-term oral anticoagulation, and may require interruption of their anticoagulation for elective surgeries or invasive...
The WOEST trial: Double vs. triple therapy in patients requiring PCI and anticoagulation [Classics...
1. In patients requiring percutaneous coronary intervention (PCI) and long-term oral anticoagulation, treating with clopidogrel alone (i.e., double therapy) significantly reduced the risk of...
Prednisolone vs placebo in severe alcoholic hepatitis [Classics Series]
1. Compared to placebo, treating patients with severe alcoholic hepatitis with 28 days of prednisolone significantly improved the short-term survival up to 6 months.
2....
Omeprazole versus placebo for bleeding peptic ulcer [Classics Series]
1. Patients presenting with upper gastrointestinal bleeds experienced significantly lower risk of continued bleeding and need for surgery to control bleeding when treated with...
The AMPLIFY trial: Apixaban for treatment of venous thromboembolism [Classics Series]
1. Apixaban was found to be non-inferior to conventional therapy (i.e., enoxaparin followed by warfarin) in the treatment of acute venous thromboembolism.
2. Major bleeding...
Vena caval filters in pulmonary embolism prophylaxis [Classics Series]
Image: PD
1. Permanent vena caval filter placement in addition to anticoagulant therapy helps prevent short-term occurrence of pulmonary embolism but increases the risk of...
Albumin in cirrhotic patients with spontaneous bacterial peritonitis [Classics Series]
1. In cirrhotic patients with spontaneous bacterial peritonitis, albumin infusion on days 1 and 3 of treatment in addition to antibiotics significantly reduces the...
Fecal transplantation in recurrent C. difficile infection [Classics Series]
1. Treating recurrent C. difficile infection with infusion of donor feces resulted in significantly higher cure rates than treating with vancomycin-alone or vancomycin with...
The OHTS trial: Topical ocular hypotensive medication reduces risk of open-angle glaucoma [Classics Series]
1. At 5 years, the probability of developing open-angle glaucoma was significantly lower in the group that received topical ocular hypotensive medication compared to...
The CARESS trial: Dual antiplatelet therapy superior to monotherapy in symptomatic carotid stenosis [Classics...
1. Dual antiplatelet therapy with clopidogrel and aspirin was associated with a significant reduction in microembolic events in patients with symptomatic carotid stenosis compared...
