Nexiguran ziclumeran reduces serum TTR levels in transthyretin amyloid cardiomyopathy
1. In this phase one clinical trial, among patients with transthyretin amyloid cardiomyopathy (ATTR-CM), it was found that nexiguran ziclumeran...
Surgery Classics
Physician-written reports of landmark surgery studies
Weekly insulin efsitora noninferior to daily degludec in reducing glycated hemoglobin levels
1. In this randomized controlled trial, insulin alfa efsitora (efsitora) demonstrated noninferiority to degludec in reducing glycated hemoglobin (HbA1c) levels...
PCI beneficial in patients undergoing transcatheter aortic-valve implantation
1. In patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) with stable coronary artery disease (CAD),...
De-escalating dual antiplatelet therapy may lower major bleeding risk following drug-eluting stent implantation
1. In this systematic review and meta-analysis, de-escalating dual antiplatelet therapy to ticagrelor monotherapy following implantation of a drug-eluting stent...
Invasive treatment not superior to medical therapy in older adults with NSTEMI
1. In this randomized controlled trial, in older adults with non-ST-segment elevation myocardial infarction (NSTEMI), invasive treatment did not significantly...
![ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]](https://www.2minutemedicine.com/wp-content/uploads/2013/05/web-cover-classics-with-logo-medicine-BW-small-jpg-350x250.jpg){kind=logo}
Child-Pugh Score: Prognosis, Classification & Cirrhosis Staging in Chronic Liver Disease [Classics Series]
1. The Child-Pugh score, derived from five clinical and lab measures (bilirubin, albumin, INR/prothrombin time, ascites, encephalopathy), is widely used...
POISE Trial: Perioperative Metoprolol Reduces MI but Increases Stroke & Mortality [Classics Series]
1. In adults undergoing noncardiac surgery, perioperative β-blocker therapy with extended-release metoprolol significantly reduced nonfatal myocardial infarction (MI) risk but...
Decision aids during surgical consultation effective in aligning patient preferences when choosing between open repair and endovascular repair for abdominal aortic aneurysms
1. In this cluster randomized trial that included 235 patients with abdominal aortic aneurysms, those who were counselled on both...
![Adverse pregnancy outcomes associated with thrombophilias [Classics Series]](https://www.2minutemedicine.com/wp-content/uploads/2015/07/Classics-2-Minute-Medicine-e1436017941513-350x250.png)
The AREDS2: No benefit from additional carotenoid and omega-3-fatty acid supplementation to original AREDS formulation [The Classics Series]
1. There was no added benefit observed with adding lutein and zeaxanthin, omega-3-fatty acids (DHA and EPA), or the combination...
The EVS: Vitrectomy results in better visual outcomes for light-perception patients [Classics Series]
1. In patients with endophthalmitis after recent lens implantation, immediate vitrectomy significantly improved visual outcomes for patients presenting with light-perception...
