• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Comparable outcomes suggested across antibiotic spectrum for pediatric CAP

byLeah Carr, MD
October 28, 2013
in Infectious Disease, Pediatrics, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Despite 2011 national clinical practice guidelines suggesting narrow-spectrum antibiotics as empiric therapy for children hospitalized with presumed community-acquired pneumonia (CAP), approximately only 10% of children are treated accordingly.

2. This study suggests no significant differences in length of stay, admissions to ICU, readmissions, or costs between children treated with narrow- vs. broad-spectrum antibiotics for pediatric CAP.

Study Rundown: Over 150,000 children are hospitalized annually with community acquired pneumonia (CAP).  These children are most often treated with empiric antibiotics before a causative organism is identified. The Pediatric Infectious Diseases Society and Infectious Diseases Society of America collaborated in 2011 to release clinical practice guidelines for the choice of empiric antibiotics for children over 3 months of age with presumed CAP. These guidelines suggest empiric coverage with either penicillin or ampicillin, which are narrow-spectrum antibiotics known to adequately cover Streptococcus pneumoniae, the most common causative  pediatric CAP organism. Despite these guidelines, research indicates that approximately only 10% of children hospitalized for CAP are treated appropriately. This observational study compared clinical and cost outcomes in children hospitalized for CAP receiving either narrow- or broad-spectrum antibiotics. Researchers found no significant difference in median length of stay (LOS), number of admissions to the ICU, readmissions, or costs between the 2 groups. Though limited by its design, this study provides additional evidence in favor of the 2011 guidelines, and suggests judicious antibiotic usage for pediatric CAP to promote proper antibiotic stewardship.

Click to read the study published today in Pediatrics

Relevant Reading: The Management of Community-Acquired Pneumonia in Infants and Children Older than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America

In-Depth [observational study]: This study examined 149 853 children aged 6 months to 18 years with an ICD-9 code for CAP at 43 freestanding, tertiary care children’s hospitals from the Pediatric Health Information System database. Children with complex chronic conditions, transfers from another hospitals, or previous hospitalization within 30 days were excluded for concern for healthcare-associated pneumonia. Additionally, children with low severity of disease (LOS < 2 days) and high severity (requiring pleural drainage, admission to ICU, mechanical ventilation, or death within first 2 days of hospitalization) were excluded. After exclusion, 13 954 (89.7%) children treated with broad-spectrum antibiotics (ceftriaxone, cefotaxime) and 1 610 (10.3%) treated with narrow-spectrum antibiotics (penicillin, ampicillin) were examined. No significant differences were found in admissions to ICU (1.1% broad v. 0.8% narrow, adjusted odds ratio: 0.85, 95% CI: 0.27 – 2.73) or readmissions (2.3% broad v. 2.4% narrow, adjusted odds ratio 0.85, 95% CI: 0.45 – 1.63). There was also no significant difference in LOS for the 2 groups(adjusted difference: 0.12 days, 95% CI: -0.02 – 0.26) or cost of hospitalization (adjusted difference: -$14.4, 95% CI: -$177.1 – $148.3).

RELATED REPORTS

Clinical response to Gram stain-guided antibiotic therapy noninferior to that of guideline-based therapy in patients with ventilator-associated pneumonia

Melioidosis outbreak is associated with imported aromatherapy spray

Immediate drainage of infected necrotizing pancreatitis shows no benefit over postponed drainage

By Neha Joshi and Leah H. Carr

More from this author: Dexamethasone efficacy suggested in high-risk infants with bronchiolitis, Antepartum and intrapartum events both linked to neonatal HIE, Adult decision rules poor proxy for diagnosing pediatric PE, Pediatric readmissions likely a poor proxy for hospital quality, Quality improvement methods increase adherence to pediatric UTI guidelines

 © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: antibioticspneumonia
Previous Post

No differences in respiratory tract infection treatments

Next Post

AAP policy statement addresses influence of media on children

RelatedReports

Prescription of antibiotics for acute respiratory infections increasing
Infectious Disease

Clinical response to Gram stain-guided antibiotic therapy noninferior to that of guideline-based therapy in patients with ventilator-associated pneumonia

April 14, 2022
Of Background Image
Chronic Disease

Melioidosis outbreak is associated with imported aromatherapy spray

March 9, 2022
Mild-to-moderate hypertriglyceridemia associated with higher risk of acute pancreatitis
Emergency

Immediate drainage of infected necrotizing pancreatitis shows no benefit over postponed drainage

February 14, 2022
Prescription of antibiotics for acute respiratory infections increasing
Infectious Disease

Shorter antibiotic course effective in children with community acquired pneumonia

January 27, 2022
Next Post
TV associated with higher BMI in teens

AAP policy statement addresses influence of media on children

Classics Series, Landmark Trials in Medicine

The ARISTOTLE trial: Apixaban vs warfarin in atrial fibrillation [Classics Series]

Increased risk of invasive meningococcal disease for patients with HIV

Increased risk of invasive meningococcal disease for patients with HIV

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Wellness Check: Sleep
  • Mediterranean diet superior to low-fat diet in secondary prevention of cardiovascular events
  • Early onset Lewy Body Dementia is more clinically distinct from Alzheimer Dementia than late onset Lewy Body Dementia
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.