Tag: antibiotics

1. In a cohort of hospitalized children, culture positivity was not associated with antibiotic pretreatment. Evidence Rating Level: 2 (Good) Osteomyelitis and septic arthritis require prompt diagnosis, long-term antimicrobial therapy, and sometimes surgical debridement to prevent significant morbidity and mortality in pediatric patients. Although empiric antibiotics are the mainstay of treatment,...
1. There was no difference in follow-up symptom severity between patients who received immediate or delayed antibiotics for respiratory tract infections. 2. Delaying antibiotics was associated with higher patient satisfaction, lower complications, and fewer reconsultations compared to not receiving any antibiotics.  Evidence Rating Level: 1 (Excellent)  Study Rundown: In 2016, the CDC...
1. In a large retrospective cohort study, adolescents prescribed fluoroquinolone antibiotics were at a slightly increased risk of experiencing tendinitis or tendon rupture compared to those who took other antibiotics. 2. The increased risk of tendon rupture associated with fluoroquinolone use was extremely small, with a number needed to treat...
1. Cure at 15 days occurred in 77% of patients in the placebo (3-day therapy) group compared to 68% of patients in the β-lactam (8-day therapy) group. 2. Incidence of adverse events was similar between both groups (14% placebo vs. 19% β-lactam).  Evidence Rating Level: 1 (Excellent) Study Rundown: Lower respiratory tract...
1. In children with S. Aureus bacteremia (SAB), follow up blood cultures (FUBCs) after two negative cultures were rarely positive. 2. Patients with osteomyelitis or endocarditis were more likely to have intermittent or prolonged positive blood cultures Evidence Rating Level: 2 (Good) Study Rundown: Staphylococcus aureus is a common and dangerous pathogen...
1. Delaying antibiotic treatment for UTI in older adults did not increase risk of bloodstream infection compared to immediate antibiotic treatment. 2. Delayed treatment may have contributed to increased risk of mortality in this group. Evidence Rating Level: 3 (Average) Urinary tract infection (UTIs) is one of the most common reasons for...
1. Afabicin, a novel, narrow-spectrum antibiotic, was found to be non-inferior to vancomycin and linezolid in treating staphylococcal skin and soft tissue infections. Evidence Level Rating: 1 (Excellent) Staphylococcus spp., especially Staphylococcus aureus, are the predominant agents responsible for many serious infections, including acute bacterial skin and skin structure infections (ABSSSIs),...
Robotic Approach to Paraesophageal Hernia Repair Results in Low Long-Term Recurrence Rate and Beneficial Patient-Centered Outcomes 1. The use of robotic techniques to repair paraesophageal hernias resulted in low rates of recurrence and had positive patient outcomes at five years. Evidence Rating Level: 3 (Average) Since the advent of laparoscopic surgery in...
1. Co-prescription of clarithromycin and direct oral anticoagulants was associated with a higher rate of 30-day hospitalization with hemorrhage when compared with co-prescription of azithromycin. Evidence Rating Level: 2 (Good) In recent years, direct oral anticoagulants (DOACs) like apixaban and rivaroxaban have overtaken vitamin K antagonists as the anti-coagulation drugs of...
1. In children aged 3 months to 18 years discharged from the emergency department (ED) with suspected community-acquired pneumonia (CAP), similar treatment failure rates were observed between children who received antibiotics and those who did not. 2. Secondary outcomes, including ED revisits within 30 days and parent-reported quality of life...