Tag: antibiotics

1. Co-prescription of clarithromycin and direct oral anticoagulants was associated with a higher rate of 30-day hospitalization with hemorrhage when compared with co-prescription of azithromycin. Evidence Rating Level: 2 (Good) In recent years, direct oral anticoagulants (DOACs) like apixaban and rivaroxaban have overtaken vitamin K antagonists as the anti-coagulation drugs of...
1. In children aged 3 months to 18 years discharged from the emergency department (ED) with suspected community-acquired pneumonia (CAP), similar treatment failure rates were observed between children who received antibiotics and those who did not. 2. Secondary outcomes, including ED revisits within 30 days and parent-reported quality of life...
1. Commonly prescribed antibiotics in infancy are associated with later diagnosis of allergic disease in childhood Evidence Rating Level: 2 (Good) The use of antibiotics negatively impacts the human microbiome, decreasing bacterial diversity. These kinds of changes to the microbiome have been previously found to be associated with allergic disease. In...
Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes: A post-hoc analysis of the PAMPer and COMBAT clinical trials 1. Prehospital plasma transfusion is associated with increased survival in the setting of hemorrhagic shock, particularly with longer transport...
1. Across the state of California, there was greater than 100-fold variability in the number of infants treated with antibiotics per proven bloodstream infection, ranging from 7.3 to 781 infants treated. 2. The number of infants exposed to antibiotics correlated strongly with the number of live births admitted to the...
1. In this prospective multicenter observational trial among adult patients with severe manifestations of sepsis, administration of antimicrobial treatment prior to collection of blood cultures resulted in significantly diminished sensitivity (52.9%). 2. Study findings demonstrated the importance of obtaining blood cultures prior to proceeding with antimicrobial therapy, strengthening the current...
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...
1. In this prospective multicenter observational trial among adult patients with severe manifestations of sepsis, administration of antimicrobial treatment prior to collection of blood cultures resulted in significantly diminished sensitivity (52.9%). 2. Study findings demonstrated the importance of obtaining blood cultures prior to proceeding with antimicrobial therapy, strengthening the current...
Antibiotic resistance is a growing challenge across the globe. As such, there have been increasing efforts towards reducing unnecessary or inappropriate antibiotic prescribing of antibiotics. There is limited evidence regarding the contribution of excessive antibiotic treatment duration to antibiotic overuse in the primary care setting. In this cross-sectional study,...
1. Very low birth weight (VLBW) infants who received antibiotics for 4 to 7 days had significant increased odds of short term morbidity and mortality. 2. Each day of antibiotic use among VLBW infants was associated with about 5% greater odds of major adverse outcomes. Evidence Rating: 2 (Good) Study Rundown: Early onset...