• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Endovascular thrombectomy 6 to 24-hours after anterior circulation stroke significantly reduces disability rates

byNeel MistryandTeddy Guo
February 1, 2022
in Chronic Disease, Neurology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Patients in the thrombectomy group reported a greater independence in daily living compared to those receiving best medical therapy alone.

2. 90-day mortality did not differ between the thrombectomy and best medical therapy groups.

Evidence Rating Level: 1 (Excellent)

Study Rundown: There exists extensive evidence around the use of mechanical thrombectomy for patients with large vessel occlusion (LVO) strokes. However, whether clinical outcomes differ if treated within 6 hours of onset compared to between 6-24 hours is unknown. This systematic review and meta-analysis aimed to assess the safety and efficacy of thrombectomy versus best medical therapy in patients with anterior circulation LVO stroke. The primary outcome was reduced disability at 90 days, measured from 0-6 on the modified Rankin Scale (mRS), while key safety outcomes included intracerebral bleeding and death. According to study results, thrombectomy was superior to medical therapy for independence in activities of daily living, with no significant difference in 90-day mortality. In addition, there was a greater treatment effect seen in patients treated with thrombectomy in the 12-to-24-hour period compared to the 6-to-12-hour window. This study was strengthened by a systematic review design that collected individual patient data from a large sample of patients over many years, adding to the validity of findings. Overall, this study endorses the use of mechanical thrombectomy for reversal or cerebral ischemia within 6-24 hours of LVO stroke.

Click to read the study in The Lancet

Relevant Reading: Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke

In-depth [systematic review and meta-analysis]: This systematic review and meta-analysis included studies on endovascular therapy from Jan 1, 2010, to Mar 1, 2021. 505 patients (266 in thrombectomy group and 239 in the best medical therapy [alteplase] group) were included from six randomized controlled trials (RCTs). Mean patient age was 68.6 years (standard deviation [SD] 13.7) with the majority (n=259, 51.3%) being female. Patients were stratified by time from last well known (6-12h and 12-24h) and randomized to either group. The primary outcome of reduced disability at 90 days was in favor of thrombectomy (adjusted odds ratio [OR] 2.54, 95% confidence interval [CI] 1.83-3.54, p<0.0001) with a greater proportion of patients experiencing independence in activities of daily living (mRS 0-2) compared to medical therapy alone (45.9% vs. 19.3%, respectively; p<0.0001). In addition, a stronger treatment effect was noted in the 12-24 hour group (common OR 5.86, 95% CI 3.14-10.94) compared to 6-12 hours (common OR 1.76, 95% CI 1.18-2.62). However, there were no significant differences between thrombectomy and medical therapy regarding intracerebral hemorrhage (5.3% vs. 3.3%) and 90-day mortality (16.5% vs. 19.3%). Findings from this study suggest that endovascular thrombectomy may be done routinely in patients with LVO stroke across a 6-24h time window.

RELATED REPORTS

2 Minute Medicine Rewind March 20, 2023

Intravenous tenecteplase non-inferior to alteplase for patients with acute ischemic strokes

Left atrial reservoir strain improves ischemic stroke risk prediction in low-risk patients

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: alteplaseanterior circulation strokeendovascular thrombectomymechanical thrombectomystrokestroke recoverythrombectomy
Previous Post

Patient and prescription factors associated with overdose after initiating opioids

Next Post

#VisualAbstract: Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation

RelatedReports

Intensive rehabilitation not superior to traditional therapy for arm function after stroke
Weekly Rewinds

2 Minute Medicine Rewind March 20, 2023

March 20, 2023
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Chronic Disease

Intravenous tenecteplase non-inferior to alteplase for patients with acute ischemic strokes

March 7, 2023
Intensive rehabilitation not superior to traditional therapy for arm function after stroke
Cardiology

Left atrial reservoir strain improves ischemic stroke risk prediction in low-risk patients

January 31, 2023
Appropriate use criteria for angiography may frequently miss obstructive coronary artery disease
Cardiology

Bivalirudin during and post-percutaneous coronary intervention reduces bleeding and mortality compared to heparin monotherapy

December 6, 2022
Next Post
#VisualAbstract: Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation

#VisualAbstract: Convalescent plasma is not effective at improving clinical outcomes or reducing mortality of COVID-19 patients not on mechanical ventilation

Physical therapy reduces pain in adults with knee osteoarthritis

Knee extensor muscle weakness may be a risk factor for osteoarthritis

2 Minute Medicine Rewind January 28, 2019

Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Mycobacterium abscessus infections after cardiac surgery linked to hospital water system
  • The 2 Minute Medicine Podcast Episode 11
  • Wellness Check: Spirituality
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options