Tag: alteplase

1. In this randomized controlled trial, low-dose intracoronary alteplase given early during primary percutaneous coronary intervention (PCI) for acute ST-Elevation Myocardial Infarction (STEMI) did not reduce microvascular obstruction. 2. Health related quality of life was not improved with low-dose intracoronary alteplase. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute coronary thrombosis causes...
1. In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at 90 days post-stroke compared to aspirin. 2. Patients treated with alteplase had a slightly higher rate of spontaneous intracranial hemorrhage but no differencesin mortality compared to...
1. In this secondary analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED), there were no significant difference in treatment effects between low and standard-dose alteplase for death or disability in acute ischemic stroke across age, ethnicity, or severity. 2. This trial did show that there were...
1. Patients with acute ischemic stroke presenting with proximal vessel occlusion, adequate collateral circulation, and small infarct size who received rapid endovascular treatment had significantly improved 90-day functional outcomes and reduced mortality when compared to those who received intravenous alteplase alone. Evidence Rating: 1 (Excellent) Study Rundown: Patients with acute ischemic...
1. Among patients with large vessel ischemic stroke and evidence of salvageable brain tissue on computed tomography (CT) perfusion imaging, endovascular thrombectomy following intravenous (IV) alteplase administration improved technical reperfusion and both early clinical and late functional outcomes when compared to IV thrombolytic therapy alone. 2. No significant differences in...
1. Alteplase (recombinant tissue plasminogen activator, or rtPA) administration within 4.5 hours hours following the onset of an ischemic stroke improves the odds of good stroke outcomes regardless of age or stroke severity, with greater proportional benefits seen with earlier treatment.  2. Administration of alteplase carried an increased risk of...