• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home The Classics General Medicine Classics

Intravenous omeprazole after endoscopy reduces rebleeding in patients with peptic ulcers [Classics Series]

bys25qthea
December 6, 2013
in General Medicine Classics, Surgery Classics, The Classics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: CC/L. academia

1. After endoscopic treatment, intravenous omeprazole significantly reduces the risk of rebleeding in patients with peptic ulcers at 3, 7, and 30 days

Original Date of Publication: August 3, 2000

Study Rundown: The findings of this trial demonstrate the value of a proton pump inhibitor in reducing the risk of rebleeding in patients with peptic ulcers. The fact that this study was carried out at a single centre in a predominantly Chinese population may limit the generalizability of the study. Moreover, the use of intravenous omeprazole is another concern, as it may not be available in certain other practice settings. Other studies, however, have demonstrated similar benefits with using orally administered proton pump inhibitors.

In sum, intravenous omeprazole reduces the risk of rebleeding in patients with bleeding peptic ulcers after endoscopic treatment.

Click to read study in NEJM

In-Depth [randomized controlled study]: This trial, published in 2000 in NEJM, sought to explore the value of intravenous omeprazole after endoscopy to reduce the risk of rebleeding in patients with peptic ulcers. After endoscopic treatment, bleeding peptic ulcers have been shown to rebleed in 15-20 percent of patients, though acid suppression may help stabilize clots and reduce the bleeding risk.

RELATED REPORTS

Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk

Airway impedance may aid diagnosis of gastroesophageal reflux and aspiration in children

MRI offers an alternative to endoscopic assessment of disease activity and severity in ileocolonic Crohn’s disease [Classics Series]

The trial was conducted at the Chinese University of Hong Kong. A total of 240 patients were randomized to receive either intravenous omeprazole (i.e., 80 mg bolus, then 8 mg/hour for 72 hours) or placebo after endoscopic treatment for bleeding peptic ulcers. Treatment with omeprazole significantly reduced the risk of recurrent bleeding at days 3, 7, and 30 compared to placebo. Moreover, omeprazole significantly reduced the length of hospitalization and blood transfusion requirements, though there were no significant differences in mortality between the two groups.

By Adrienne Cheung, Andrew Cheung, M.D.

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain.

Tags: endoscopyomeprazolepeptic ulcers
Previous Post

Chlorhexidine bathing significantly reduces the development of hospital-acquired blood-stream infections

Next Post

Study hints at causal link between lipoprotein(a) and calcific aortic stenosis

RelatedReports

Benefits of high-intensity surveillance following colorectal adenoma removal likely outweigh costs
Chronic Disease

Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk

March 20, 2023
Quick Take: Comparison of Laparoscopic 270 Degree Posterior Partial Fundoplication vs Total Fundoplication for the Treatment of Gastroesophageal Reflex Disease: a Randomized Clinical Trial  
Chronic Disease

Airway impedance may aid diagnosis of gastroesophageal reflux and aspiration in children

December 8, 2022
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
Radiology Classics

MRI offers an alternative to endoscopic assessment of disease activity and severity in ileocolonic Crohn’s disease [Classics Series]

August 11, 2022
Gastric bypass surgery reduces cardio-metabolic risk factors
Gastroenterology

Significant morbidity among children observed following reintroduction of high-powered magnets into US market

February 10, 2022
Next Post

Study hints at causal link between lipoprotein(a) and calcific aortic stenosis

Surgical crisis checklists improve performance during operating-room crisis simulations

Ethical argument for opt-out approach to DNR status in terminally ill children

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Childhood maltreatment may cause mental health problems
  • #VisualAbstract: Hydrochlorothiazide does not impact risk of kidney-stone recurrence
  • Metformin use may decrease risk of osteoarthritis development
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options