• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Low and middle-income countries show greater post-operative mortality following cancer surgery

byMichael PratteandTeddy Guo
February 9, 2021
in Chronic Disease, Oncology, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Low- and middle-income countries have a higher 30-day mortality in colorectal and gastric cancer surgeries compared with high-income countries.

2. Although the rate of peri-operative complications was similar across all country income levels, patients in low or lower-middle income countries were more likely to die from these events.

Evidence Rating Level: 2 (Good)

Study Rundown: As cancer prevalence increases in low- and middle-income countries (LMIC), oncological surgical care is increasingly utilized for treatment in these areas. Despite the increasing prevalence, however, there exists little information regarding the demographics of cancer in LMICs, or statistics involving surgical treatment of these cancers. Little is known about factors associated with morbidity and mortality in the surgical treatment of breast, colorectal and gastric cancer in LMICs. This multicenter, prospective cohort study sought to characterize the mortality and complication rates for surgical treatments of breast, colorectal and gastric cancers in low-, middle- and high-income countries. Overall, patients in upper-middle and LMICs underwent operation for their cancer at a more advanced stage. When adjusted for patient and disease factors relative to hospital and country of treatment, 30-day mortality was greater for gastric and colorectal cancers, but not breast cancer, in low- and lower-middle income countries compared to high-income countries. Complication rates were similar across all country income levels. However, a higher percentage of patients who sustained a major perioperative complication that lead to death was found in low- and lower-middle-income countries versus high-income countries. In terms of this study’s strength, this was a well-powered study with a prospective design, that collected data from a wide range of hospitals across the world. An important limitation, however, was only including 30-day postoperative mortality, and not a longer period of time. This is especially important to acknowledge given the longitudinal and chronic nature of most cancers.

Click to read the study in The Lancet

Relevant Reading: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

RELATED REPORTS

Breast cancer survivors may have a lower risk of Alzheimer’s dementia

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

#VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer

In-Depth [prospective cohort]:  This international, multicenter, prospective cohort study included a total of 15,958 patients in their analysis across 420 hospitals in 82 countries around the world. All patients were adults undergoing their first surgery for either primary breast, colorectal or gastric cancer. The primary outcome measures were 30-day mortality and 30-day major complication rate (including death). Secondary outcomes included rates of any complications at 30 days. Overall, 9106 (57.1%) of patients were from high-income, 2721 (17.0%) from middle-income, and 4131 (25.9%) from low- or lower-income countries. About half of the patients had surgery for breast cancer (52.7%), over a third for colorectal cancer (38.9%) and 8.4% had gastric cancer surgery.

After adjusting for patient and disease factors, as well as hospital and country of treatment, gastric cancer had a higher 30-day mortality rate in low- or lower-middle-income countries versus high-income countries (adjusted odds ratio [aOR] =3.72, 95% confidence interval [CI] 1.79-8.15). Colorectal cancer saw a higher 30-day mortality rate in upper-middle (aOR = 2.06, 95% CI 1.11-3.83) and low- or lower-middle-income countries versus high-income (aOR = 4.59, 95% CI 2.39-8.80). No difference in mortality was seen in breast cancer surgery. While the rate of major complications was similar across all groups, patients in upper-middle-income and LMICs were more likely to die following a major perioperative complication versus high-income countries (aOR = 3.89, 95% CI 2.08-7.29 and aOR = 6.15, 95% CI 3.26-11.59, respectively). Mortality following major complication was associated with the absence of postoperative care in LMICs (adjusted OR=1.19, 95%CI 1.01-1.42) and upper-middle-income groups (adjusted OR=1.19, 95% CI 1.01-1.42).

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Breast Cancercolorectal cancergastric cancerincome disparitylow-income and middle-income countriesoncologysurgical outcomes
Previous Post

Mental health, overdose, and violence outcomes and the COVID-19 pandemic

Next Post

Lower oxygenation does not improve mortality in hypoxemic respiratory failure

RelatedReports

AI Roundup

Breast cancer survivors may have a lower risk of Alzheimer’s dementia

June 26, 2025
3D mammography (tomosynthesis) enhances accuracy of breast cancer screening
Chronic Disease

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

June 25, 2025
#VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer
StudyGraphics

#VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer

June 17, 2025
Patient Basics: Stomach Cancer
AI Roundup

Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer

June 16, 2025
Next Post
Pulmonary MRI with ultrashort echo time is comparable to pulmonary CT

Lower oxygenation does not improve mortality in hypoxemic respiratory failure

Primary care physicians play substantial role in pediatric mental health

Naltrexone-bupropion treatment provides a higher response for methamphetamine use disorder

#VisualAbstract: Tocilizumab is superior to rituximab for treatment of rheumatoid arthritis in patients with low or absent B-cell lineage expression

#VisualAbstract: Adavosertib plus gemcitabine improves survival in platinum-resistant recurrent ovarian cancer

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
  • 2 Minute Medicine Rewind June 30, 2025
  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.