• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

M72/AS01E demonstrates sustained efficacy against pulmonary tuberculosis after 3 years

byThomas SuandDeepti Shroff Karhade
November 23, 2019
in Infectious Disease, Public Health, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups.

2. Participants in Kenya and South Africa displayed different patterns of CD4+ T-cell expression, suggesting that cellular differentiation may have been affected by infection-related, vaccine-induced, and ethnic-group factors.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Tuberculosis is the leading cause of death from a single pathogen and a top ten cause of death worldwide. M72/AS01E, an adjuvanted recombinant candidate vaccine, has previously been shown to be effective in preventing pulmonary tuberculosis in HIV-negative adults with latent M. tuberculosis infection in Kenya, South Africa, and Zambia. This study aimed to extend those results after an additional year of follow-up, finding that overall vaccine efficacy continued to hover around 50% with similar rates of adverse events and death between the treatment and placebo groups. All persons in the treatment group who were selected for inclusion in the immunogenicity cohort exhibited significantly increased frequencies of polypositive M72-specific CD4+ T cells and remained seropositive through month 36. However, there were no instances of progression to active pulmonary tuberculosis in this subgroup, meaning that no correlation between immune response and protection could be established. The persistence of these effects is encouraging, but the study findings need to be confirmed in larger, more diverse populations and across longer timeframes.

Click here to read the study in NEJM

Relevant Reading: Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis

RELATED REPORTS

Poor baseline lung function associated with increased risk of incident tuberculosis

Artificial intelligence demonstrates non-inferiority to radiologists at tuberculosis detection within a population with a high-disease burden

The 2 Minute Medicine Podcast Episode 55

In-Depth [randomized controlled trial]: In this double-blind trial conducted in three African countries where tuberculosis is endemic, 3575 adults were randomly assigned in a 1:1 ratio to receive two doses of either M72/AS01E or placebo, administered 1 month apart. The efficacy cohort consisted of all participants who received at least one dose and were not found to have had active tuberculosis at any point prior to study enrollment, and the immunogenicity cohort consisted of the first 150 participants enrolled at each of two major centers. Using an unadjusted Cox regression model accounting for a mean follow-up of 2.7 years, the overall vaccine efficacy at month 36 was determined to be 49.7% (95% CI, 2.1 to 74.2) with 13 cases of active pulmonary tuberculosis in the treatment group (rate/100 person-years, 0.3; 90% CI, 0.2 to 0.5) and 26 cases in the placebo group (rate/100 person-years, 0.6; 90% CI, 0.4 to 0.8). Adjusting for several factors including country, sex, age, and previous bacille Calmette-Guérin vaccination yielded nearly identical results. Participants in the treatment group exhibited a substantial increase in both anti-M72 IgG antibody concentration and frequency of polypositive M72-specific CD4+ T-cells with predominant expression of interferon-γ, interleukin-2, and TNF-α. No CD8+ T-cell responses were detected in either group. Overall mortality was lower in the treatment group (relative risk, 0.68; 95% CI, 0.36 to 1.26; P=0.24), and only one serious adverse event related to the trial regimen occurred in each group, with onset on the day of administration.

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: BCGM72/AS01Etuberculosisvaccine
Previous Post

Closed-loop insulin delivery systems may improve glycemic outcomes compared to sensor-augmented pumps

Next Post

Association of Sex With Outcomes in Patients Undergoing Percutaneous Coronary Intervention

RelatedReports

Lessons from real-world implementation of lung cancer screening
Chronic Disease

Poor baseline lung function associated with increased risk of incident tuberculosis

May 9, 2025
Significant number of wrong-patient errors in radiology reports
2 Minute Medicine

Artificial intelligence demonstrates non-inferiority to radiologists at tuberculosis detection within a population with a high-disease burden

April 10, 2025
The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 55

April 5, 2025
The Scan by 2 Minute Medicine: The Role of Virtual Reality in Pain Management, WHO’S controversial diagnosis on gaming addictions, the TikTok ban and psychology of doom scrolling, and the risk of smart devices replacing annual checkups
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Triple Attack Against Endometriosis, Vaccines and Autism, Revisited, The Final Frontier of Human Health, and Eating Well to Live Better:

April 1, 2025
Next Post
Lisinopril and carvedilol reduce cardiotoxicity in breast cancer patients receiving trastuzumab and anthracyclines

Association of Sex With Outcomes in Patients Undergoing Percutaneous Coronary Intervention

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

2 Minute Medicine Rewind August 12, 2019

2 Minute Medicine Rewind November 25, 2019

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Cerebral embolic protection does not decrease stroke incidence in TAVI patients
  • Nerandomilast slows FVC decline in progressive pulmonary fibrosis
  • 2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.