Tag: tuberculosis

1. When compared to 9 months of isoniazid, 4 months of rifampin was a non-inferior alternative treatment of latent tuberculosis (TB) that was both cheaper and lead to lower healthcare usage amongst adult and pediatric patients in high-, middle-, and low-resource health systems in 9 nations. 2. Choosing rifampin represented...
1. Empiric systemic treatment for tuberculosis was shown not to be better than test-guided treatment among severely immunosuppressed adults with human immunodeficiency virus (HIV) infection. 2. Systemic treatment for tuberculosis was associated with more grade 3 and 4 drug-related adverse events compared to test-guided treatment. Evidence Rating Level: 1 (Excellent) Study Rundown:...
Electronic Cigarette and JUUL Use Among Adolescents and Young Adults 1. The use of electronic cigarettes is highly prevalent among adolescents and young adults through the advent of JUUL, which has unique implications for this young and susceptible age group. Evidence Rating Level: 1 (Excellent) Adverse effects of nicotine on overall health,...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...
Tuberculosis (TB) is the leading cause of death by an infectious disease. Identifying affected individuals, particularly if they are asymptomatic, however, remains a challenge as the infectious organisms are primarily contained within lung granulomas and/or draining lymph nodes. Biomarkers in the host’s blood compartment may be used in identifying...
Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis Fetal presentation has long been determined by way of clinical examination only, despite the relative ease with which breech presentation can be identified through ultrasound screening. As such, many women continue to present in...
1. A randomized control trial of patients with multidrug resistant tuberculosis found that shorter treatment regimens were noninferior to longer treatment regimens currently recommended by the WHO. 2. Severe adverse events were noted in both arms including death, QT interval prolongation and increases in alanine transaminase (ALT) levels. Evidence Rating Level:...
1. A randomized control trial of patients with multidrug resistant tuberculosis found that shorter treatment regimens were noninferior to longer treatment regimens currently recommended by the WHO. 2. Severe adverse events were noted in both arms including death, QT interval prolongation and increases in alanine transaminase (ALT) levels. Evidence Rating...
1. Children with tuberculosis (TB) who received 3 months of directly observed preventative therapy (DOPT) were >25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy (SAT). 2. Children who received 9-month isoniazid therapy via DOPT had >30% higher rates of completion...