Tag: tuberculosis

1. After 3 years of weekly vitamin D supplementation, the proportion of children who tested positive on interferon-gamma release assays was similar to that of the placebo group 2. No between-group differences were detected in the incidences of tuberculosis disease or acute respiratory infection during this period. Evidence Rating Level: 1 (Excellent) Study...
1. When compared to 9 months of isoniazid, 4 months of rifampin was a non-inferior alternative treatment of latent tuberculosis (TB) that was both cheaper and lead to lower healthcare usage amongst adult and pediatric patients in high-, middle-, and low-resource health systems in 9 nations. 2. Choosing rifampin represented...
1. After 3 years of weekly vitamin D supplementation, the proportion of children who tested positive on interferon-gamma release assays was similar to that of the placebo group 2. No between-group differences were detected in the incidences of tuberculosis disease or acute respiratory infection during this period. Evidence Rating Level: 1...
1. Expression of IFN-α is found to be lower after successful treatment of tuberculosis. Evidence Rating Level: 2 (Good) Tuberculosis (TB) is an infectious disease killing over 1 million people annually worldwide, caused by the bacterium M. tuberculosis (M.tb). The immune response to TB involves T cells that express signalling proteins...
1. When compared to 9 months of isoniazid, 4 months of rifampin was a non-inferior alternative treatment of latent tuberculosis (TB) that was both cheaper and lead to lower healthcare usage amongst adult and pediatric patients in high-, middle-, and low-resource health systems in 9 nations. 2. Choosing rifampin represented...
1. Empiric systemic treatment for tuberculosis was shown not to be better than test-guided treatment among severely immunosuppressed adults with human immunodeficiency virus (HIV) infection. 2. Systemic treatment for tuberculosis was associated with more grade 3 and 4 drug-related adverse events compared to test-guided treatment. Evidence Rating Level: 1 (Excellent) Study Rundown:...
Electronic Cigarette and JUUL Use Among Adolescents and Young Adults 1. The use of electronic cigarettes is highly prevalent among adolescents and young adults through the advent of JUUL, which has unique implications for this young and susceptible age group. Evidence Rating Level: 1 (Excellent) Adverse effects of nicotine on overall health,...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...
Tuberculosis (TB) is the leading cause of death by an infectious disease. Identifying affected individuals, particularly if they are asymptomatic, however, remains a challenge as the infectious organisms are primarily contained within lung granulomas and/or draining lymph nodes. Biomarkers in the host’s blood compartment may be used in identifying...