• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

No significant difference found at 5-year follow-up between bilateral and single CABG: The ART trial

byShaidah Deghan, MSc. MD
December 30, 2016
in Cardiology, Chronic Disease, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. At 5-years of follow-up, there were no significant differences in the rates of mortality and cardiovascular outcomes when comparing patients treated with bilateral or single internal-thoracic-artery coronary-artery bypass grafting (CABG).

2. There was a significantly higher rate of sternal wound complications observed in the bilateral group compared to the single group.

Evidence Rating: 1 (Excellent)

Study Rundown: One of the most commonly performed operations for the treatment of symptomatic multivessel coronary artery disease is CABG. The procedure involves an anastomosis of the left internal thoracic (mammary) artery (LIMA) to the left anterior descending (LAD) coronary artery. In cases where grafts are required, saphenous vein or radial artery grafts to bypass the other arteries may be used. The LIMA to LAD approach has resulted in over 90% patency rate at 10 years compared to 50% for vein grafts. This has resulted in the proposal to use a bilateral internal-thoracic-artery approach. However, the complexity of the procedure, higher risk of sternal wound complications, and lack of randomized evidence has hindered its popularity. Hence, the Arterial Revascularization Trial (ART) was initiated to compare the 10-year survival of bilateral compared to single artery grafting. At 5 years of follow-up, there were no significant differences between the two groups in the rates of mortality or cardiovascular events. There was a higher rate of sternal wounds in the bilateral group compared to the single group. The study is limited given that it is an interim analysis of a 10-year project.

Click to read the study, published today in NEJM

Relevant Reading: A meta-analysis of adjusted hazard ratios from 20 observational studies of bilateral versus single internal thoracic artery coronary artery bypass grafting

In-Depth [randomized controlled trial]: A total of 3102 patients were enrolled in this multicenter, randomized trial that took place at 28 cardiac surgical centers in 7 countries. Participants were randomly assigned to either single or bilateral internal-thoracic-artery grafting. The primary outcome was death from any cause at 10 years of follow-up. Secondary outcomes included a composite of death from any cause, myocardial infarction, or stroke, quality of life, rate of repeat revascularization, safety outcomes, and cost effectiveness.

RELATED REPORTS

Unmarried status associated with an increased risk of mortality in Asian populations

#VisualAbstract: CT associated with lower complication risks than invasive coronary angiography

Mediterranean diet superior to low-fat diet in secondary prevention of cardiovascular events

This publication was an interim analysis performed at 5 years after follow-up. The rate of death was 8.7% in the bilateral group compared to 8.4% in the single group and there was no significant difference between the two groups (HR 1.04, 95%CI 0.81-1.32; p = 0.77). There was no significant difference between the two groups in the rate of death from any cause or myocardial infarction (HR 0.96; 95%CI 0.79-1.17; p = 0.69). However, the rate of sternal wound complication was significantly higher in the bilateral group at 3.5% compared to the single group at 1.9% (p = 0.005).

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Coronary artery diseasecoronary bypass
Previous Post

Cardiovascular outcomes are similar for arthritis patients treated with selective and nonselective NSAIDs

Next Post

Effect of a primary care-based psychological intervention on common mental disorders in Zimbabwe

RelatedReports

Parents desensitized with increasing exposure to movie violence/sex
Cardiology

Unmarried status associated with an increased risk of mortality in Asian populations

June 1, 2022
#VisualAbstract: CT associated with lower complication risks than invasive coronary angiography
StudyGraphics

#VisualAbstract: CT associated with lower complication risks than invasive coronary angiography

June 1, 2022
FDA-approved weight loss medications associated with weight loss at one year
Cardiology

Mediterranean diet superior to low-fat diet in secondary prevention of cardiovascular events

May 25, 2022
SARS-CoV-2 is associated with higher incidence of Kawasaki disease in children
Cardiology

Systematic review of Kawasaki disease shows excellent long-term survival

February 9, 2022
Next Post
Earlier puberty associated with increased risk of depression in girls

Effect of a primary care-based psychological intervention on common mental disorders in Zimbabwe

Diabetes and ischemic heart disease account for highest personal health care spending in U.S.

Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • The RAPTURE trial: Radiofrequency ablation effective and safe in lung cancer [Classics Series]
  • Relugolix combination therapy is efficacious for endometriosis-associated pain
  • Age-based products and longer interdose intervals may reduce the risk of cardiac disease following COVID-19 mRNA vaccination
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.