• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Neurology

Nonnutritive sweeteners elicit more neural response to food cues compared to sugar

byYidi WangandAvneesh Bhangu
October 20, 2021
in Neurology, Wellness
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this study, nonnutritive sweeteners (NNS) resulted in higher circulating levels of glucose, insulin, and glucagon-like peptide 1 (GLP-1) compared to nutritive sugars (NS).

2. Obesity and female gender were associated with greater neural response to food cues after consuming NNSs compared to NSs.

Evidence Rating Level: 1 (Excellent)

Nonnutritive sweeteners (NNSs) are a common ingredient in low-caloric food and beverages. However, how NNSs impact appetite, neural responses to high-calorie food cues, and metabolic responses compared to nutritive sugar (NS) remains understudied.

This randomized cross-over trial examined brain activity, metabolic responses, and eating behaviors after consumption of NNS compared to NS amongst 74 healthy young adults across a wide range of body mass indices (BMIs) at the Dornsife Cognitive Neuroimaging Center of University of Soutern California. Participants fasted for 12 hours prior to consuming drinks containing either NNS, NS, or water, randomized for each of three visits. Blood was sampled pre- and post- consumption to measure metabolic outcomes. Participants also underwent functional magnetic resonance imaging (fMRI) testing approximately 20 minutes after ingestion of the drink and were allowed to eat ad libitum 125 minutes after the drink. Participants with a history of eating disorder, diabetes, or other medical conditions were excluded. Primary outcomes of interest were effect of BMI and sex on metabolic and neural responses to high-calorie food cues following NNS vs NS consumption.

Compared to NS, NNS consumption resulted in higher circulating glucose, insulin, and GLP-1 levels. Individuals with obesity (but not overweight or health-weight individuals) exhibited greater neural responses to food images in reward-related regions of the brain after ingesting NNS compared to NS. In addition, female participants responded with increased neural food-cue reactivity after NNS consumption compared to male participants. This study was limited in having just a one time, one-dose exposure to NNS vs NS, considering consumption of NNS is usually more prolonged and sustained. Nonetheless, this study was significant in suggesting certain biological factors may influence the effects of NNS.

RELATED REPORTS

Time-restricted eating does not confer changes in sleep, mood, or quality of life

Semaglutide improves walking ability in patients with peripheral artery disease and type 2 diabetes

Vegetarianism may be associated with a small increased risk of hypothyroidism

Click to read the study in JAMA Network Open

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: appetitedietglp-1glucoseinsulinsugarsweetenerwellness
Previous Post

#VisualAbstract: Increasing the number of SARS-CoV-2 immune family members associated with decreasing risk of infection in nonimmune individuals

Next Post

#VisualAbstract: Fulvestrant-palbociclib and letrozole-palbociclib are equally effective for HR⁺ advanced breast cancer

RelatedReports

Provision of medically-tailored meals linked with lower admissions and medical spending
Chronic Disease

Time-restricted eating does not confer changes in sleep, mood, or quality of life

July 4, 2025
Increased number of daily steps linked with decreased mortality in older women
Chronic Disease

Semaglutide improves walking ability in patients with peripheral artery disease and type 2 diabetes

May 29, 2025
Thyroidectomy more effective than medication for Hashimoto disease with persisting symptoms
Chronic Disease

Vegetarianism may be associated with a small increased risk of hypothyroidism

May 16, 2025
Food environment associated with gestational diabetes
Pharma

Eli Lilly Takes Legal Action Against Telehealth Startups

May 15, 2025
Next Post
#VisualAbstract: Fulvestrant-palbociclib and letrozole-palbociclib are equally effective for HR⁺ advanced breast cancer

#VisualAbstract: Fulvestrant-palbociclib and letrozole-palbociclib are equally effective for HR⁺ advanced breast cancer

Lessons from real-world implementation of lung cancer screening

Adjuvant atezolizumab shows benefit in patients with stage II-IIIA non-small-cell lung cancer

Novel coronavirus identified from patients with pneumonia in Wuhan, China

Treatment of immune-mediated inflammatory diseases with tumor necrosis factor inhibitors is associated with lower COVID-19 hospitalization and death rates compared to other treatments

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Time-restricted eating does not confer changes in sleep, mood, or quality of life
  • Commonly cited medication triggers may not increase risk of microscopic colitis among older adults
  • Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.