Tag: insulin

1. In this study, nonnutritive sweeteners (NNS) resulted in higher circulating levels of glucose, insulin, and glucagon-like peptide 1 (GLP-1) compared to nutritive sugars (NS). 2. Obesity and female gender were associated with greater neural response to food cues after consuming NNSs compared to NSs. Evidence Rating Level: 1 (Excellent) Nonnutritive sweeteners...
1. Patients receiving tirzepatide (5, 10, or 15 mg) reported significantly greater reductions in HbA1c compared to daily insulin degludec at 52 weeks post-randomization. 2. Tirzepatide (5, 10, or 15 mg) was superior to insulin degludec for the bodyweight reductions at 52 weeks post-randomization. Evidence Rating Level: 1 (Excellent) Study Rundown: Current...
1. Among adults with poorly controlled type 2 diabetes treated with basal insulin without prandial insulin, continuous glucose monitoring resulted in significantly lower hemoglobin A1c levels at 8 months when compared with conventional blood glucose meter monitoring. 2. Patients using continuous glucose monitoring also had significantly improved secondary outcomes including...
1. In this randomized, double-blind, phase two trial, the use of golimumab led to more C-peptide production, indicative of improved endogenous function, compared to placebo in new type 1 diabetics. 2. Patients that received golimumab used less exogenous insulin compared to placebo. Evidence Rating Level: 2 (Good) Study Rundown: TNF-α has been...
1. In this randomized, double-blind, phase two trial, the use of golimumab led to more C-peptide production, indicative of improved endogenous function, compared to placebo in new type 1 diabetics. 2. Patients that received golimumab used less exogenous insulin compared to placebo. Evidence Rating Level: 2 (Good) Study Rundown: TNF-α has been...
1. The closed-loop system maintained glucose levels within the target range for a significantly greater percentage of time for children with type 1 diabetes. 2. More adverse events were reported with use of the closed-loop system. Evidence Rating Level: 1 (Excellent) Study Rundown: The target glycated hemoglobin level is difficult to maintain...
1. Insulin costs steadily increased from 2006-2017. However, the out-of-pocket costs to privately insured patients remained consistent, in-part due to decreased cost-sharing. 2. Privately insured consumers with health savings accounts (HSAs) paid significantly more in out of pocket costs in comparison to those with health reimbursement arrangements (HRAs) or no-account...
1. In this randomized noninferiority trial involving newborns with asymptomatic moderate hypoglycemia, initiation of treatment at a lower blood glucose threshold resulted in no significant difference in psychomotor development at 18 months versus the traditional threshold. 2. Fewer hypoglycemic episodes occurred in the traditional threshold group, although more invasive interventions...
1. In this randomized controlled trial, patients with type 1 diabetes who used a closed-loop system spent a greater percentage of time in a target glycemic range compared to those who used a sensor-augmented insulin pump. 2. The closed-loop system was effective in reducing glycated hemoglobin level as well as...
1. In this large, longitudinal cohort study from the United States, patients with poor health status were more likely to continue insulin use compared with healthier patients. Evidence Rating Level: 2 (Good) Study Rundown: Type 2 Diabetes Mellitus (DM2) is one of the most common chronic illnesses in the world. Glycemic...