Tag: insulin

1. In this retrospective cohort study, mean HbA1c levels decreased prior to systematic implementation of a program to switch from analogue to human insulin, after which HbA1c levels then increased slightly and remained steady. 2. Serious hypoglycemic or hyperglycemic events were not significantly different with program implementation. Evidence Rating Level: 2...
1. Basal insulin analogues do not differ significantly in providing glucose control. 2. Some insulin formulations may have more favorable effects on patient weight compared to others. Evidence Rating Level: 1 (Excellent) Study Rundown: Type 2 diabetes (T2DM) has significant morbidity if untreated and affects a large proportion of North Americans annually....
1. In this retrospective cohort study, for patients with type 2 diabetes, initiation of a basal insulin analog compared with NPH insulin was not associated with a reduced risk of hypoglycemia-related ED visits or hospital admissions. 2. Though NPH insulin led to a small but significantly greater decrease in HbA1c...
1. In this randomized controlled trial, glyburide was not non-inferior in terms of the composite rate of macrosomia, neonatal hypoglycemia, and hyperbilirubinemia compared with subcutaneous insulin. 2. Women taking glyburide had better glycemic control and were more likely to prefer glyburide for subsequent pregnancies but also had higher rates of...
1. Treatment with insulin degludec resulted in a lower rate of overall symptomatic hypoglycemic episodes compared with insulin glargine U100. 2. Rates of nocturnal symptomatic hypoglycemia were also lower with insulin degludec compared with insulin glargine U100. Evidence Rating Level: 1 (Excellent) Study Rundown: Hypoglycemia is a problem with many insulin-treated patients...
  Sunscreen use and subsequent melanoma risk: a population-based cohort study Exposure to solar ultraviolet (UV) radiation is a known risk factor in the development of cutaneous melanoma. While research has shown that the use of sunscreen decreases the risk of sunburn, squamous cell carcinoma, actinic keratosis and nevi in children,...
1. In this small randomized controlled trial, addition of glucagon-like peptide 1 receptor agonist, liraglutide, to patients with type-2 diabetes receiving high-dose insulin therapy was associated with improved glycated hemoglobin (HbA1c) levels, weight loss, and patient satisfaction at six months. 2. Liraglutide therapy was associated with more hypoglycemic events during...
1. Glucose-responsive vesicles (GRVs), nanoscale polymer spheres loaded with glucose oxidase (GOx) enzyme, released insulin cargo in response to hyperglycemic conditions in vitro. 2. In a mouse model of type 1 diabetes, GRVs were delivered transcutaneously via polymer microneedle (MN)-array patches and normalized blood glucose levels over several hours...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Cytisine versus Nicotine for Smoking Cessation When compared with placebo, cytisine, a partial nicotinic acetylcholine receptor agonist, has been shown to nearly double the chance of smoking cessation at 6 months. This...
1. Compared to other anti-diabetic regimens, patients treated with a GLP-1 agonist and basal insulin combination had a greater mean reduction of HbA1c levels. 2. The GLP-1 agonist and basal insulin combination was associated with significant weight loss in study participants. Evidence Rating Level: 1 (Excellent) Study Rundown: Type...