Tag: insulin
1. In this small randomized controlled trial, addition of glucagon-like peptide 1 receptor agonist, liraglutide, to patients with type-2 diabetes receiving high-dose insulin therapy was associated with improved glycated hemoglobin (HbA1c) levels, weight loss, and patient satisfaction at six months.
2. Liraglutide therapy was associated with more hypoglycemic events during...
1. Glucose-responsive vesicles (GRVs), nanoscale polymer spheres loaded with glucose oxidase (GOx) enzyme, released insulin cargo in response to hyperglycemic conditions in vitro.
2. In a mouse model of type 1 diabetes, GRVs were delivered transcutaneously via polymer microneedle (MN)-array patches and normalized blood glucose levels over several hours...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week.
Cytisine versus Nicotine for Smoking Cessation
When compared with placebo, cytisine, a partial nicotinic acetylcholine receptor agonist, has been shown to nearly double the chance of smoking cessation at 6 months. This...
1. Compared to other anti-diabetic regimens, patients treated with a GLP-1 agonist and basal insulin combination had a greater mean reduction of HbA1c levels.
2. The GLP-1 agonist and basal insulin combination was associated with significant weight loss in study participants.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Type...
1. An average American born between 2000 and 2011 was estimated to have a 40% probability of developing diabetes during their lifetime.
2. The greatest lifetime risks were seen in Hispanic men and women and non-Hispanic black women, in which lifetime diabetes risks increased to over 50%.
Evidence Rating Level: 3...
1. Continuous insulin pumps were more effective than multiple daily insulin injections at lowering glycated hemoglobin (HbA1c), as well as 24-hour mean blood glucose concentrations levels in type II diabetes patients.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Many patients with advanced type II diabetes require insulin treatment, which may involve...
1. The addition of insulin to metformin was associated with an increased risk of all-cause mortality and an increased grouped risk of all-cause mortality and myocardial infarction (MI) or stroke relative to the addition of sulfonylureas.
2. The addition of insulin versus sulfonylureas to metformin did not differ in terms...
Image: PD
1. In a 20 year follow-up study (DIGAMI 1 trial), intensive insulin-based glycemic control for 3 months after an initial acute myocardial infarction (MI) in type 2 diabetics increased survival by 2.3 years compared to standard glycemic control.
2. The mortality benefits of intensive insulin-based glycemic control was most...
Image: PD
In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week.
Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa
Tuberculosis (TB) is difficult to diagnose microbiologically in children, as the majority of childhood cases produce negative smears and cultures...
Image: CC?Wiki
1. Plasma insulin levels at birth and early childhood were found to be inversely proportional to gestational age.
2. Elevated plasma insulin levels at birth may lead to high insulin levels in early childhood.
Evidence Rating Level: 2 (Good)
Study Rundown: Ever increasing rates of diabetes, cardiovascular disease, and other mostly...