• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Better glucose control with closed-loop system in children with type 1 diabetes

byConstance Wu
September 3, 2020
in StudyGraphics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. The closed-loop system maintained glucose levels within the target range for a significantly greater percentage of time for children with type 1 diabetes.

2. More adverse events were reported with use of the closed-loop system.

Evidence Rating Level: 1 (Excellent)

Study Rundown: The target glycated hemoglobin level is difficult to maintain for children with type 1 diabetes. Furthermore, current insulin delivery systems require the user to manually inform the technology of the insulin bolus during mealtimes. A recently approved closed-loop system automates insulin delivery in a glucose responsive manner, thereby, not requiring the user to interface with the technology during mealtimes. This study investigated the safety and efficacy of the closed-loop system in children with type 1 diabetes. The results of the study determined that the closed-loop system enabled the children to attain the target glycated hemoglobin level range for a greater percentage of time compared to the sensor-augmented insulin pump. This randomized trial was limited by the represented trial population, as it was unable to encompass the general population affected by type 1 diabetes in regards to socioeconomic status and glycated hemoglobin levels. Nonetheless, the results of this study were strengthened because participant enrollment was not restricted based on prior severe hypoglycemia or diabetic ketoacidosis.

Click to read the study, published today in NEJM

In-Depth [randomized controlled trial]: This randomized control trial enrolled 101 participants in a multicenter study in the United States. Participants included in the study were between 6 and 13 years of age, diagnosed with type 1 diabetes and received insulin treatment for at least 6 months. Participants with a total daily insulin dose of less than 10 units were excluded from this study. The participants were randomized in a 3:1 ratio to the closed-loop system or the control group, respectively. The control group used the sensor-augmented insulin pump. The primary outcome of the study was the percentage of time that the participant’s glucose levels were within the target range, which was defined as between 70 to 180 milligrams per deciliter. After 16 weeks of treatment, the mean (±SD) percentage of time the glucose level was within the target range increased from 53±17%, at baseline, to 67±10% in the closed-loop group. Similarly, the mean (±SD) percentage of time the glucose level was within the target range increased from 51±16%, at baseline, to 55±13% in the control group. The mean adjusted difference between both groups was 11 percentage points (95% confidence interval [CI], 7 to 14; P<0.001). Furthermore, the percentage of time the glucose level was within the target range favored the closed-loop system across various characteristics such as age, sex, and household income. At the end of treatment, the mean (±SD) glycated hemoglobin level was 7.0±0.8% in the closed-loop group compared to 7.6±0.9% in the control group (between-group difference, -0.4 percentage points; 95% CI, -0.9 to 0.1; P=0.08). Within the closed-loop group, 39 participants (51%) met the glycemic target for glycated hemoglobin level of less than 7% compared to 4 participants (18%) in the control group. Finally, 16 adverse events were reported in the closed-loop group (number of events per 100 person-years, 65.3) compared to 3 adverse events in the control group (number of events per 100 person-years, 41.3; P=0.50). Specifically, 14 events of hyperglycemia or hyperketosis caused by infusion set failure were reported for the closed-loop group compared to 1 such event in the control group. Taken together, the closed-loop system maintained glucose levels within the target range for a significantly greater percentage of time compared to the sensor-augmented insulin pump across a variety of participant characteristics.

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

The Scan by 2 Minute Medicine®: Erythritol and Heart Problems, Maternal Health Trends, the Next Big Thing in Diabetes, and Declining Levels of Sea Ice

The 2 Minute Medicine Podcast Episode 3

The Scan by 2 Minute Medicine®: the New Cost of Insulin, Beyond IVF, the Spotlight on RSV and Influenza, and Theranos Founder Sentenced to 11 Years!

Tags: closed-loop systemcontinuous glucose monitoringhba1cinsulint1dmtype 1 diabetesType 1 Diabetes Mellitus
Previous Post

Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia

Next Post

Incorporating pharmacists into kidney care model may reduce inappropriate prescription rates

RelatedReports

The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Erythritol and Heart Problems, Maternal Health Trends, the Next Big Thing in Diabetes, and Declining Levels of Sea Ice

March 7, 2023
2MM Podcast

The 2 Minute Medicine Podcast Episode 3

February 9, 2023
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: the New Cost of Insulin, Beyond IVF, the Spotlight on RSV and Influenza, and Theranos Founder Sentenced to 11 Years!

November 30, 2022
Updated USPSTF guidelines favor treatment of mild gestational diabetes
Cardiology

Continuous glucose monitoring in type 1 diabetes results in improved blood glucose levels

October 26, 2022
Next Post
Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

Incorporating pharmacists into kidney care model may reduce inappropriate prescription rates

SARS-CoV-2 detected on various surroundings of asymptomatic COVID-19 positive infant

Serum IL-6 and TNF-α levels identified as independent predictors of COVID-19 severity and mortality

Age and breast cancer risk factors associated with false-positive mammography results

Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Active surveillance strategies to improve rates of inferior vena cava filter retrieval
  • Intranasal vaccine against Bordetella pertussis invokes seronegative IgA response
  • Hydrochlorothiazide does not impact risk of kidney-stone recurrence
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options