Tag: Type 1 Diabetes Mellitus

Intensive glycemic control has been shown to reduce the risk of retinopathy and nephropathy in the setting of type 1 diabetes. While prior studies have established that an elevated hemoglobin A1C (HbA1C) is an independent risk factor for diabetic complications, few studies have followed patients from the time of...
1. In relatives of patients with type 1 diabetes (T1DM) at risk for disease development, randomization to teplizumab delayed time to T1DM diagnosis compared to placebo treated patients. 2. Adverse events associated with teplizumab treatment included rash and transient lymphopenia. Evidence Rating Level: 1 (Excellent)   Study Rundown: T1DM results from autoimmune destruction...
Type 1 diabetes (T1D) is thought to result from a combination of genetic and environmental factors. An increased intake of dietary fiber and gluten has been hypothesized to contribute to the development of T1D, though supporting data is scarce. In this cohort study, 6,081 infants with human leukocyte antigen...
Pregnancy duration and endometrial cancer risk: nationwide cohort study Full-term pregnancies are strongly associated with a reduced risk of endometrial cancer. Whether this protective association is driven by fecundity, a specific process that occurs during pregnancy, or cumulative number of months pregnancy, however, is unknown. In this cohort study, 2,311,332...
1. In relatives of patients with type 1 diabetes (T1DM) at risk for disease development, randomization to teplizumab delayed time to T1DM diagnosis compared to placebo treated patients. 2. Adverse events associated with teplizumab treatment included rash and transient lymphopenia. Evidence Rating Level: 1 (Excellent)   Study Rundown: T1DM results from autoimmune...
1. In this prospective cohort study, adolescents with type 1 diabetes (T1D) were noted to be more likely to have persistently elevated distress levels if they were female, had elevated initial hemoglobin A1c (HbA1c) levels, reported the low self-care behaviors, higher levels of depression and anxiety, and increased disease-related...
1. In this prospective cohort study, adolescents with type 1 diabetes (T1D) were noted to be more likely to have persistently elevated distress levels if they were female, had elevated initial hemoglobin A1c (HbA1c) levels, reported the low self-care behaviors, higher levels of depression and anxiety, and increased disease-related...
Multiple daily injections (MDI) and continuous subcutaneous insulin infusion (CSII) are two forms of intensive insulin regimens utilized by patients with type 1 diabetes. Here, MDI and CSII are compared in terms of their safety, efficacy, and cost in the first year after a diagnosis of type 1 diabetes....
1. In this Danish retrospective cohort study, there was no association between standardized reading and mathematics test scores and type 1 diabetes. 2. Among those with diabetes, there was an association between test scores and HbA1c levels. Evidence Rating Level: 2 (Good)            Study Rundown: Type 1 diabetes is associated with microvascular and...
1. A survey of individuals with type 1 diabetes mellitus (T1DM) consuming a very low-carbohydrate diet (VLCD) indicated that many study participants were able to maintain glycemic control within national ideal glycemic target ranges. 2. Complications, including hospitalizations for ketoacidosis and hypoglycemia, were rare in the study population. Study Rundown:...