• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Percutaneous intervention outcomes for STEMI similar for women and men

byAnees DaudandJames Jiang
September 29, 2014
in Cardiology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. This meta-analysis of outcomes after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) showed that women fared similarly to men in terms of hospital mortality and 1-year mortality, after adjusting for major confounding variables.

2. There were major differences in the baseline characteristics between women and men, with women having higher cardiovascular risk profile, older age at time of presentation, and a greater prevalence of diabetes, hypertension, and hyperlipidemia.

Evidence Rating Level: 1 (Excellent) 

Study Rundown: Coronary artery disease (CAD) accounts for 1 in 6 deaths amongst Americans. However, there has been a significant reduction in mortality associated with CAD in the last decade, due mostly to modifying cardiovascular risk and improving acute care during myocardial infarctions. An example of this is primary percutaneous coronary intervention (PPCI) as the mainstay of reperfusion therapy for ST-segment elevation myocardial infarction (STEMI). One observation that has often been made is that women have worse outcomes than men after PPCI. This systematic review and meta-analysis of the data on PPCI after a STEMI was done to identify sex-specific differences in outcomes. The results of this study suggest that there are significant baseline differences between women and men that confound the results. After taking these into consideration, the study found that women fared similarly to men in terms of hospital mortality and 1-year mortality.

The major strength of this study was that almost all relevant studies were included in the analysis since the inclusion criteria were fairly general. The investigators also showed the unadjusted and adjusted data to highlight the important effects of the confounders. The weakness of the study was that most of the studies were observational, rather than randomized studies. Also, there were significant differences in the protocol and outcome determination amongst the various studies, as is often the case in any meta-analysis.

Click to read the study, published today in JAMA Internal Medicine

Relevant Reading: Comparison of left ventricular function following first ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention in men versus women

RELATED REPORTS

#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease

Oral P2Y12 inhibitor pretreatment offers no benefit in non-ST elevation acute coronary syndromes

The timing of administering aspirin and nitroglycerin in patients with STEMI ECG changes alter patient outcome

In-Depth [meta-analysis]: The investigators included a wide array of reliable search tools to obtain the included studies. The relevant inclusion criteria for the studies included the following: study type had to be observational or a randomized controlled trial, PPCI was the therapy of choice for the STEMI, PPCI was done within 12 hours of symptom onset, and the studies had to report in-hospital and 1-year mortality results. A total of 35 studies were included in the analysis, 31 of which were observational.

The meta-analysis identified a number of confounding baseline differences between women and men, including women having higher cardiovascular risk profile, older age at presentation, and a greater prevalence of diabetes, hypertension, and hyperlipidemia. As a result, the investigators reported both unadjusted and adjusted relative risk ratios. For in-hospital all-cause-mortality, the unadjusted results showed an increased risk for women relative to men (RR 1.93; 95%CI 1.75-2.14). However, the adjusted results showed a much more attenuated risk, albeit still statistically significant (RR 1.48; 95%CI 1.07-2.05). Similarly, for 1-year all-cause-mortality, the unadjusted results again showed an increased risk for women (RR 1.58; 95%CI 1.36-1.84). However, no significant risk was identified after adjusting for confounders (RR 0.90; 95%CI 0.69-1.17).

More from this author: Mechanical aortic valve replacement linked with increased early mortality, Proton pump inhibitor boluses as effective as infusions in ulcer bleeds, Intensity of medical residency may affect future practice style, Coronary angiography in asymptomatic patients may lead to inappropriate percutaneous interventions, Blood clot prophylaxis medicine inpatient may be unnecessary

Image: PD

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: ACSmeta-analysisSTEMI
Previous Post

Fenoldopam ineffective for renal injury after cardiac surgery

Next Post

Ixekizumab may be safe and effective for chronic plaque psoriasis

RelatedReports

#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease
StudyGraphics

#VisualAbstract Psoriasis is associated with an increase in incident venous thromboembolism and peripheral vascular disease

December 16, 2021
Propofol appears safe and effective in procedural sedation for cardioversion
Cardiology

Oral P2Y12 inhibitor pretreatment offers no benefit in non-ST elevation acute coronary syndromes

May 13, 2022
Using HEART score to risk stratify patients with chest pain is safe but underutilized in the ED
Cardiology

The timing of administering aspirin and nitroglycerin in patients with STEMI ECG changes alter patient outcome

November 24, 2021
Colchicine may lower the risk of cardiovascular events in patients with coronary disease
Cardiology

Sex differences in cardiovascular outcomes of older adults after myocardial infarction

November 8, 2021
Next Post
Ixekizumab may be safe and effective for chronic plaque psoriasis

Ixekizumab may be safe and effective for chronic plaque psoriasis

Novel biodegradable sirolimus-eluting stents non-inferior to durable everolimus-eluting stents [BIOSCIENCE trial]

Effectiveness of medical device postapproval surveillance unclear

Ebola outbreak projected to exceed 20,000 cases by November

2 Minute Medicine Rewind September 22 – September 29, 2014

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Mediterranean diet superior to low-fat diet in secondary prevention of cardiovascular events
  • Early onset Lewy Body Dementia is more clinically distinct from Alzheimer Dementia than late onset Lewy Body Dementia
  • Pelvic lymph node radiotherapy and androgen deprivation therapy augment progression-free status following prostatectomy
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.