• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Prophylactic implantable cardioverter-defibrillators may decrease mortality in left ventricular dysfunction

byReshmi MadankumarandPriyanka Vedak
June 8, 2014
in Cardiology, Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Survival at 3 years was significantly better in patients with a left ventricular ejection fraction (LVEF) between 30% and 35% and an implantable cardioverter-defibrillator (ICD) compared to matched patients without an ICD. 

2. Survival at 3 years was also significantly better in patients with LVEF < 30% and an ICD compared to matched patients without an ICD. 

Evidence Rating Level: 2 (Good)            

Study Rundown: Implantable cardioverter-defibrillators (ICDs) prevent sudden cardiac death in patients with systolic heart failure and low left ventricular ejection fraction (LVEF). Randomized clinical trials have investigated the survival benefit of prophylactic ICDs using the inclusion criteria of LVEF < 35%. However, most participants in these studies have LVEFs much lower than 30% and the outcomes of patients with LVEF between 30% and 35% have not been well studied.

This study examined the survival benefit of prophylactic ICD placement in patients with a LVEF between 30% and 35% and those with a LVEF less than 30%, and found a benefit at 3 years post-placement for both. This study was limited by its restriction to Medicare patients and the incomplete nature of some aspects of the clinical databases that were utilized. Thus, future studies may aim to increase the generalizability of these findings and may be able to capture more complete data through a prospective approach. Moreover, additional measures may be examined in addition to all-cause mortality, such as quality of life and procedural complications. Nevertheless, at this time, this study demonstrates the survival benefit of prophylactic ICD placement in patients with LVEF less than 35%.

Click to read the study in JAMA

Relevant Reading: Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction

RELATED REPORTS

Torsemide not associated with significant difference in all-cause mortality over 12 months compared to furosemide – The TRANSFORM-HF randomized clinical trial

Clinical decision-making strategy improves acute heart failure outcomes

Ferric derisomaltose may reduce heart failure-related hospitalizations

In-Depth [retrospective cohort]: This study was a retrospective cohort in which patients with an LVEF between 30 and 35% who received a prophylactic ICD during a heart failure hospitalization (n=408) were matched to patients with no ICD (n=408). At 3 years, 51.4% of the patients with prophylactic ICD had died compared to 55.0% of the patients without ICDs, demonstrating a significantly lower risk of mortality in patients with an ICD (HR 0.83 [95% CI 0.69-0.99], p=0.4).  The same analysis was performed on patients with LVEF < 30% with a prophylactic ICD (n=1088) matched to patients with no ICD (n=1088). At 3 years, 45.0% of patients with ICDs had died compared to 57.6% of the patients without ICDs. Similarly, patients with ICDs had a significantly lower risk of mortality (HR 0.72 [95% CI, 0.65-0.81], p<0.001).

More from this author: The VIDA trial: Vitamin D3 does not improve outcomes in asthma patients

Image: CC/Wiki

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: heart failureICD
Previous Post

No effect seen with early chemotherapy modification in elevated CTC breast cancer

Next Post

Rotavirus vaccination associated with decreased rates of health care utilization

RelatedReports

Radiation dose associated with increased heart disease in Hodgkin lymphoma survivors
Cardiology

Torsemide not associated with significant difference in all-cause mortality over 12 months compared to furosemide – The TRANSFORM-HF randomized clinical trial

January 24, 2023
Remote patient monitoring did not reduce heart failure readmissions: The BEAT-HF trial
Cardiology

Clinical decision-making strategy improves acute heart failure outcomes

January 12, 2023
No association found between length of storage for transfused red blood cells and patient mortality
Cardiology

Ferric derisomaltose may reduce heart failure-related hospitalizations

December 27, 2022
Quick Take: Association of African Ancestry with Electrocardiographic Voltage and Concentric Left Ventricular Hypertrophy: The Dallas Heart Study
Cardiology

No known association between PCSK9 gene variants and risk of heart failure

December 22, 2022
Next Post
Rotavirus vaccine associated with increased risk of intussusception

Rotavirus vaccination associated with decreased rates of health care utilization

Buccal administration of dextrose gel effective for neonatal hypoglycemia

Possible benefit in omega-3 supplementation for extremely preterm infants

Pro-vaccine messages not associated with increased vaccination intent

Varicella vaccination not associated with increased adolescent disease burden

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options