• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Prothrombin complex concentrate noninferior to plasma infusion for patients with post-cardiopulmonary bypass coagulopathy

byMichael WongandAlex Chan
July 8, 2022
in Cardiology, Hematology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In patients with post-cardiopulmonary bypass coagulopathy, therapy with prothrombin complex concentrate was similar in overall safety and efficacy and had fewer complications compared to plasma infusion.

Evidence Rating Level: 1 (Excellent)

In surgical practice, post-cardiopulmonary bypass (CPB) coagulopathy is one of the most frequent reasons for requiring blood transfusions. Contributing factors to coagulopathies post-surgery include thrombocytopenia, platelet dysfunction, and coagulation factor consumption and dilution. Patients with factor-mediated coagulopathy and bleeding post-CPB often receive large volume plasma transfusions; however, there are many risks of plasma transfusions including lung injury, infectious complications, and allergic reactions. In recent years, the use of prothrombin complex concentrates in the treatment of coagulation factor-mediated bleeding post-cardiac surgery is becoming increasingly common due to lower risks and complications compared to plasma transfusions. As such, this randomized control trial aimed to investigate the safety and efficacy of prothrombin complex concentrate (PCC) compared to using plasma in patients undergoing cardiac surgery. A total of 100 adult participants undergoing CPB were included. Participants were randomly assigned to receive either PCC or plasma and were required to have excessive microvascular bleeding, determined by prothrombin greater than 16.6 seconds, to be included in the final analysis. Postoperative bleeding, evaluated by chest tube output, was assessed in all patients. The results of this study showed that there was no significant difference in postoperative bleeding between the PCC and plasma groups (median 937, IQR 708-1443 and median 1022, IQR 799-1575, respectively). Additionally, fewer participants in the PCC group required intraoperative transfusion after therapy compared to the plasma group (13.6% and 30.6%, respectively) and 13.6% of PCC participants avoided allogenic transfusion as opposed to 0% in those receiving plasma. In conclusion, this trial indicates that in patients receiving cardiac surgery with coagulopathic complications, PCC may be a safer and more effective alternative to plasma transfusion. Given that this is the first randomized control trial comparing PCC and plasma in this context, further research investigating efficacy and long-term adverse events could be very valuable.

Click to read the study in JAMA Surgery

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

2 Minute Medicine Rewind June 30, 2025

Evaluating scar outcomes in pediatric burn patients following skin grafting 

Transcatheter closure of patent ductus arteriosus demonstrates similar outcomes compared to surgical repair

Tags: hematologySurgerythrombosis
Previous Post

BNT162b2 booster dose associated with reduced risk of SARS-CoV-2 infection and mortality among older adults in long-term care facilities

Next Post

Characteristics of COVID-19 pneumonia patients [Classics Series]

RelatedReports

Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind June 30, 2025

June 30, 2025
Pediatrics

Evaluating scar outcomes in pediatric burn patients following skin grafting 

June 26, 2025
Colchicine may lower the risk of cardiovascular events in patients with coronary disease
Cardiology

Transcatheter closure of patent ductus arteriosus demonstrates similar outcomes compared to surgical repair

June 13, 2025
Weekly Rewinds

2 Minute Medicine Rewind June 9, 2025

June 9, 2025
Next Post
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

Characteristics of COVID-19 pneumonia patients [Classics Series]

Strict tobacco licensing laws linked to reduced adolescent smoking initiation

Pharmacy based smoking cessation programs not found to be effective in increasing quit rates in community settings

Colchicine may lower the risk of cardiovascular events in patients with coronary disease

EMERGE trial: Delayed coronary angiogram noninferior for patients with out of hospital cardiac arrest

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Intravaginal conjugated oestrogen does not improve continuation rate of ring pessary use
  • Artificial intelligence based clinical decision systems are safe and effective for diabetes management
  • Epic Launchpad propels generative-AI into everyday hospital routines
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.