• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Quick Take: Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans

byArnav Agarwal, MDandAliya Ramjaun
June 10, 2019
in Cardiology, Chronic Disease, Gastroenterology, Nephrology, Oncology, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Adjuvant erythropoietin therapy does not improve survival in newborns with hypoxic-ischemic encephalopathy

10-second one-legged stance performance may predict survival in middle-aged and older individuals

COVID-19 patient characteristics across Mainland China [Classics Series]

Proton pump inhibitors (PPIs) are widely used in the management of gastroesophageal reflux. However, several studies have demonstrated serious adverse events associated with PPI use including cardiovascular disease, acute kidney injury, chronic kidney disease, dementia, pneumonia, gastric cancer, Clostridium difficile infection, and increased risk of fracture. Recent evidence has also suggested an increased risk of all-cause mortality. To estimate all-cause and cause-specific mortality with acid suppression, a longitudinal cohort study of 214,467 United States veterans newly using histamine H2 receptor antagonists (H2RAs) (n=157,625) or PPIs (n=56,842) between July 2002 and June 2004 was conducted. Department of Veterans Affairs databases were used to obtain data regarding demographic characteristics, encounters with the healthcare system (both inpatient and outpatient), comorbidities, procedures, surgeries, laboratory results, outpatient prescription records, and date and underlying cause of death. With a 10-year follow-up, 45.20 excess deaths per 1,000 patients taking PPIs were reported (95% CI 28.20 to 61.40). PPI use was also associated with increased circulatory system diseases (number of attributable deaths per 1000 patients 17.47, 95% CI 5.47 to 8.80), neoplasms (12.94, 95% CI 1.24 to 24.28), infectious and parasitic diseases (4.20, 95% CI 1.57 to 7.02) and genitourinary system diseases (6.25, 95% CI 3.22 to 9.24). Cumulative duration of PPI use was associated with increased all-cause mortality. The results of this study therefore suggest an increase in cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer-related death with PPI use, warranting greater stewardship regarding PPI prescription and usage. 

Click to read the study in BMJ

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: acid suppressionGERDH2-blockersmortalityproton pump inhibitor (PPI)
Previous Post

Decline in pediatric herpes zoster associated with varicella vaccine

Next Post

2 Minute Medicine Rewind June 10, 2018

RelatedReports

Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia
Emergency

Adjuvant erythropoietin therapy does not improve survival in newborns with hypoxic-ischemic encephalopathy

July 19, 2022
Exercise improves aromatase inhibitor-induced arthralgia in breast cancer survivors
Chronic Disease

10-second one-legged stance performance may predict survival in middle-aged and older individuals

July 15, 2022
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
COVID-19 Classics

COVID-19 patient characteristics across Mainland China [Classics Series]

July 11, 2022
Exercise improves aromatase inhibitor-induced arthralgia in breast cancer survivors
Chronic Disease

Regular physical activity associated with lower all-cause and cause-specific mortality compared with physical inactivity

July 8, 2022
Next Post
Few high school students, young adults get HIV testing

2 Minute Medicine Rewind June 10, 2018

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets

Quick Take: Ultra-processed food intake and risk of cardiovascular disease

No association found between length of storage for transfused red blood cells and patient mortality

Blood transfusions from female, previously pregnant, or sex-discordant donors do not increase mortality

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin D deficiency may be associated with sleep disorders in children
  • Prasinezumab therapy does not affect Parkinson’s Disease progression
  • Prior syncope presentation not associated with increased risk of motor vehicle collision
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.