• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Rates of intussusception increase with rotavirus vaccine

byMohammad MertabanandCordelia Ross
August 24, 2016
in Gastroenterology, Infectious Disease, Pediatrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In children aged 6 to 14 weeks, rates of hospitalization from intussusception post-vaccination with the rotavirus vaccine were significantly elevated by 46% to 101%.

2. No change was observed in the hospitalization rate from intussusception in children 15 to 34 weeks of age.

Evidence Rating Level: 2 (Good)

Study Rundown: Recent studies have identified intussusception as a potential harmful side effect after the first dose of the rotavirus vaccine. In fact, a rotavirus vaccine brand was withdrawn from the market in 1999 because of the increased risk of intussusception after its introduction. The objective of this study was to compare pre-vaccine intussusception hospitalization rates with post-vaccine rates amongst children for whom the vaccine is indicated. This study added four additional years of data to previous research that examined the rates of hospitalization for intussusception after rotavirus vaccination; results of this study were found to be consistent with previous data. Findings indicated that hospitalization rates varied between the different age groups. Although children 6-14 weeks of age had the lowest rate of intussusception hospitalization among all age groups studied, this rate significantly increased post vaccination. Rates of hospitalization in all of the other age groups had no significant increase. This study was limited by the fact that vaccination data was not available in the databased used. In addition, this study used ICD-9 codes to identify intussusception hospitalizations and no attempts were made to confirm the diagnosis. This study was restricted to 26 states, thus, possibly limiting its generalizability. Furthermore, cases managed in the outpatient setting were not captured by this data. Nonetheless, despite these findings, providers should keep in mind that given the magnitude of the decreased rates of rotavirus before and after the development of the vaccine, the benefits far exceed the small increased risk of intussusception.

Click to read the study, published today in Pediatrics 

Relevant Reading: Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop

RELATED REPORTS

The 2 Minute Medicine Podcast Episode 55

The Scan by 2 Minute Medicine®: Triple Attack Against Endometriosis, Vaccines and Autism, Revisited, The Final Frontier of Human Health, and Eating Well to Live Better:

The 2 Minute Medicine Podcast Episode 54

In-Depth [ecologic analysis]: Using the State Inpatient Databases (SID), which captures inpatient data from community hospitals at participating sites in 26 states, data was extracted from 2000 to 2013. Trends in intussusception rates and hospitalizations were observed over time and analyzed further by age groups. Rates of intussusception in 2004 before the vaccine was introduced ranged from 33.9 to 37.2 per 100000 children less than 12 months of age between 2003 and 2005. After introduction of the vaccine, rates of intussusception were significantly elevated in 2007 and 2010, 40.7 per 100000 children (RR 1.13, 95% CI: 1.07–1.20) and 40.3 per 100000 children (RR 1.12, 95%CI: 1.06-1.20), respectively. Trends in hospitalizations varied from group to group. For example, in the pre-vaccine era from 2000 to 2005, the average rate of hospitalization from intussusception was 15.0 per 100000 children ages 6 to 14 weeks. In contrast, in the post-vaccine years, this group’s hospitalization rate was significantly elevated by 25% to 50%. Similarly, in the 8-11 week age group, hospitalization rates were significantly elevated by 46% to 101% (range: 16.7-22.9 per 100000), except in 2011 and 2013, where there was no significant increase. For children aged 15 to 24 weeks, hospitalization rates pre and post-vaccine introduction were similar.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: intussusceptionrotavirusvaccinationvaccine
Previous Post

Live influenza pediatric vaccination not associated with better protection than inactivated vaccine

Next Post

Use of prescription drugs affecting fracture risk not changed after fracture

RelatedReports

The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 55

April 5, 2025
The Scan by 2 Minute Medicine: The Role of Virtual Reality in Pain Management, WHO’S controversial diagnosis on gaming addictions, the TikTok ban and psychology of doom scrolling, and the risk of smart devices replacing annual checkups
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Triple Attack Against Endometriosis, Vaccines and Autism, Revisited, The Final Frontier of Human Health, and Eating Well to Live Better:

April 1, 2025
The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 54

March 21, 2025
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Measles Outbreak, Tariffs and Healthcare, Pope’s Pneumonia, and Removing Fluoride from Water:

March 18, 2025
Next Post
Ultrasound enhances gastrointestinal absorption of drugs at low frequencies

Use of prescription drugs affecting fracture risk not changed after fracture

HOSPITAL score predicts risk of 30-day potentially avoidable readmission to hospital

Team-based care systems compare favorably with traditional practice models

Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ

70-gene signature test may accurately determine prognosis in early stage breast cancer

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer
  • Fecal microbiota transplantation may be more effective than vancomycin in treating primary C. difficile infection
  • Frailty scores alone may be poor predictors of intensive care admission or hospital stay duration
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.