• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

SGLT-2 inhibitors not associated with increased risk for severe UTI

byCaitlyn HuiandDeepti Shroff Karhade
July 31, 2019
in Chronic Disease, Endocrinology, Infectious Disease
Reading Time: 2 mins read
1
Share on FacebookShare on Twitter

1. No significant difference in severe UTIs was observed between patients starting SGLT-2 inhibitors for type 2 diabetes, compared to DPP-4 inhibitors or GLP-1 agonists.

Evidence Rating Level: 2 (Good)

Study Rundown: The sodium glucose cotransporter-2 (SGLT-2) inhibitors are a newer class of diabetic medications that act by inhibiting glucose reabsorption in the proximal tubule, thereby reducing serum glucose levels. Since SGLT-2 inhibitors increase the availability of glucose in the urinary tract, there is concern the mechanism might promote bacterial growth. Studies have suggested that SGLT-2 inhibitors increase the risk of mild and moderate urinary tract infections (UTIs); however, findings are currently conflicting. This study utilized two large databases of U.S. commercial claims. The primary aim was to assess whether the initiation of SLGT-2 inhibitor therapy was associated with increased risk for severe UTIs. Inclusion criterion consisted of patients with type 2 diabetes, ages 18 or older, and had initiated SGLT-2 use, versus DPP-4 inhibitors or GLP-1 agonists. The study found that SGLT-2 inhibitors were not associated with increased risk for severe UTI compared with other anti-diabetic medications.. One limitation of this study was that the patient cohort was restricted to those with commercial insurance; therefore, the study results may not be fully generalizable to other patient groups.

Click to read the study in Annals of Internal Medicine

Relevant Reading: Dose response of sodium glucose cotransporter-2 inhibitors in relation to urinary tract infections: a systematic review and network meta-analysis of randomized controlled trials

In-Depth [retrospective cohort study]: A population-based cohort study was conducted to assess the relationship between SGLT-2 inhibitors and frequency of UTIs compared to other diabetic medications. Data was retrieved from 2 large U.S. based databases of commercial claims from March 2013 to September 2015. There were two main cohorts of patients. In the first cohort, patients starting SGLT-2 inhibitors were compared with those starting a dipeptidyl peptidase-4 (DPP-4) inhibitor. The second cohort included patients starting use of an SGLT-2 inhibitor compared to a glucagon-like peptide-2 receptor (GLP-1) agonist. Patients at high risk of UTI development were excluded from the study.  Following inclusion and exclusion criteria, cohort 1 consisted of 86 665 patients using SGLT-2 inhibitors and 136 741 patients using DPP-4 inhibitors; cohort 2 consisted of 107 289 patients using SGLT-2 inhibitors and 67 871 patients using GLP-1 agonists. Logistic regression was utilized to calculate propensity scores. After propensity scores were calculated, the SGLT-2 inhibitor group resulted in 61 severe UTI events (IR, 1.76 cases per 1000 person-years) compared to 59 in the DPP-4 inhibitor group (IR, 1.77 cases per 1000 person-years). These values correspond to an adjusted HR of 0.98 (CI, 0.68 to 1.41). Similarly, there were 73 events in the SGLT-2 inhibitor group IIR, 2.15 cases per 1000 person-years) and 87 events in the GLP-1 agonist group in cohort 2 (IR, 2.96 cases per 1000 person years), resulting in a HR of 0.72 (CI, 0.53 to 0.99).

RELATED REPORTS

Type 2 diabetes and abnormal amyloid concentrations are associated with accelerated brain atrophy

#VisualAbstract: Cagrilintide-Semaglutide is Effective for Weight Loss in Adults with Overweight or Obesity and Type 2 Diabetes

Artificial intelligence based clinical decision systems are safe and effective for diabetes management

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: diabetesDPP-4 inhibitorsGLP-1 agonistSGLT-2 inhibitorsurinary tract infection (UTI)
Previous Post

#VisualAbstract: Social Robots for Hospitalized Children

Next Post

Quick Take: The state of hypertension care in 44 low-income and middle-income countries

RelatedReports

Chronic Disease

Type 2 diabetes and abnormal amyloid concentrations are associated with accelerated brain atrophy

July 7, 2025
#VisualAbstract: Cagrilintide-Semaglutide is Effective for Weight Loss in Adults with Overweight or Obesity and Type 2 Diabetes
StudyGraphics

#VisualAbstract: Cagrilintide-Semaglutide is Effective for Weight Loss in Adults with Overweight or Obesity and Type 2 Diabetes

July 7, 2025
Pediatric DKA associated with recent acute care visits
Chronic Disease

Artificial intelligence based clinical decision systems are safe and effective for diabetes management

July 3, 2025
Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Chronic Disease

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

July 2, 2025
Next Post
Blood pressure variability associated with cardiovascular disease and mortality

Quick Take: The state of hypertension care in 44 low-income and middle-income countries

No survival benefit with ICDs in non-ischemic systolic heart failure: The DANISH trial

Cardiac device implantation complications vary widely among hospitals

Warning labels on sugar-sweetened beverages impact parent decisions

2 Minute Medicine Rewind July 15, 2019

Please login to join discussion

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Brain Activation Measured on Functional MRI Predicts Response to Certolizumab, a TNF Inhibitor, in Rheumatoid Arthritis
  • 2 Minute Medicine Rewind July 14, 2025
  • New obesity framework may reclassify over half of overweight individuals as people with obesity
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.