• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Supplemental vitamin D does not reduce risk of fractures in older adults

byBryant LimandKiera Liblik
August 16, 2022
in Chronic Disease, Orthopedic Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. There were no significant differences in total, non-vertebral, or hip fractures between the supplemental vitamin D and placebo groups of older adults.

2. Differences in fracture incidence remained insignificant after controlling for ethnicity, body mass index, age, and baseline vitamin D levels.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Bone fractures are major public health issues in older adults. Vitamin D is implicated in bone formation pathways and vitamin D supplements are widely recommended to promote bone health and prevent fractures. However, there is conflicting evidence for the efficacy of supplemental vitamin D on bone fracture prevention. The present study used data from the randomized controlled Vitamin D and Omega-3 Trial (VITAL) to evaluate the safety and efficacy of supplemental vitamin D for lowering fracture risk as compared to a placebo. There were no significant differences between groups in the incidence of total, non-vertebral, or hip fractures at five-year follow-up. The incidences of major osteoporotic, pelvic, and wrist fractures were also not significantly different between groups. The differences remained nonsignificant after considering demographic characteristics, personal use of supplemental calcium or vitamin D, and baseline 25-hydroxyvitamin D levels. There were no significant differences in the incidence of adverse events between groups. As a limitation, this is an ancillary study of VITAL, which was not specifically designed to evaluate the effect of vitamin D supplementation on bone health. As part of VITAL, participants in both supplemental vitamin D and placebo groups were further randomized to receive omega-3 fatty acid, which may affect study findings.

Click to read the study in NEJM

In-Depth [randomized control trial]: In the present study, men over the age of 50 and women over the age of 55 in the United States were randomized into vitamin D supplementation (n=12,927) and placebo (n=12,944) groups. Participants in each group were then randomized 1:1 to receive omega-3 fatty acid supplementation and a placebo. This study presented the main effects of vitamin D compared to placebo, as analysis showed no interaction between vitamin D and omega-3 fatty acid in fracture outcomes. Participants received a placebo or 2000 international units (IU) of cholecalciferol per day and were followed for a median of 5.3 years. A total of 1,991 fractures were confirmed in 1,551 participants on medical record review. There were no significant differences between vitamin D and placebo groups for incidence of total (769 and 782 participants respectively), non-vertebral (721 and 744 participants respectively), and hip fractures (57 and 56 participants respectively). Controlling for baseline age, sex, ethnic group, body mass index, personal use of supplemental calcium or vitamin D, or 25-hydroxyvitamin D levels did not result in significant differences in fracture risk. Further, the groups had no significant differences in major osteoporotic, pelvic, or wrist fractures. Supplemental vitamin D did not result in more adverse events, such as hypercalcemia or kidney stones. Study findings suggest that vitamin D supplementation does not confer increased protection against bone fractures among older adults.

Image: PD

RELATED REPORTS

Higher body mass index may be associated with altered vitamin D levels and metabolism

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: bone healthcalciumchronic diseasefracturesgeriatric medicineorthopedic surgerypreventative medicinevitamin d
Previous Post

Hepatic arterial phase imaging more sensitive than portal venous phase in the detection of hepatic lesions and arterioportal shunting [Classics Series]

Next Post

CT-guided percutaneous lung biopsies more effective for larger pulmonary nodules [Classics Series]

RelatedReports

Sleep duration inversely related to childhood type 2 diabetes risk makers
Chronic Disease

Higher body mass index may be associated with altered vitamin D levels and metabolism

January 27, 2023
β-blockers linked to improved survival in preserved ejection fraction heart failure
Cardiology

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

January 27, 2023
Brain lesions on MRI linked with subsequent increased stroke risk
Chronic Disease

Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia

January 27, 2023
2 Minute Medicine Rewind May 20, 2019
Chronic Disease

Chronic obstructive pulmonary disease associated with worse postoperative outcomes

January 26, 2023
Next Post
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]

CT-guided percutaneous lung biopsies more effective for larger pulmonary nodules [Classics Series]

Patient Basics: Atherosclerosis

Atherosclerotic risk factors associated with stroke in adulthood present from childhood and increase with age

Primary care physicians play substantial role in pediatric mental health

2 Minute Medicine Rewind August 8, 2022

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • 2 Minute Medicine Rewind January 23, 2023
  • Disposable elevator cap duodenoscopes may reduce contamination in endoscopic retrograde cholangiopancreatography – the ICECAP trial
  • Higher body mass index may be associated with altered vitamin D levels and metabolism
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options