• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Nephrology

Supraphysiological perioperative oxygen associated with worse outcomes

byAikansha ChawlaandAlex Chan
December 6, 2022
in Nephrology, Pulmonology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Supraphysiological oxygen administration during surgery is associated with higher incidence of kidney, myocardial and lung injury

Evidence Rating Level: 2 (Good)

Greater than 80% of patients undergoing general anesthesia are exposed to oxygen administration higher than that required to maintain normal blood oxygen levels. There are potentially harmful effects of supplemental oxygen administration, however, due to the consequences of hypoxemia, supplemental oxygen is a common component of anesthesia. This retrospective cohort study included 350, 657 patients who underwent surgical procedures longer than 120 minutes under general anesthesia and measured clinical outcomes based on level of oxygen exposure including acute kidney injury (measured using the Kidney Disease Improving Global Outcomes) myocardial injury (defined as a troponin >0.04 ng/mL within 72 hours of operation) and lung injury (defined using the international classification of diseases hospital discharge diagnosis codes). For each patient, minute to minute FiO2 and SpO2 data were obtained, and the amount of oxygen that was in excess was determined. The incidence of acute kidney injury, myocardial infarction and lung injury were higher in those who received oxygen levels at supraphysiological levels; for example, those at the 75th percentile of oxygen levels had a 26% greater odds of acute kidney injury, 12% greater odds of myocardial injury, and 14% greater odds of lung injury compared to those at the 25th percentile. The observational nature of this study and discrepancies on general diagnosis of these injuries (for example the use of diagnosis codes to identify lung injury) are a few limitations to this study. Future studies are needed to identify the best intraoperative oxygen administration guidelines, knowing that both hypoxemia and supraphysiological oxygen may be associated with adverse events.

Click to read the study in BMJ

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

RELATED REPORTS

Minimally invasive surgery is beneficial for epithelial ovarian cancer 

2 Minute Medicine Rewind June 30, 2025

Evaluating scar outcomes in pediatric burn patients following skin grafting 

Tags: anesthesiologynephrologySurgery
Previous Post

Bivalirudin during and post-percutaneous coronary intervention reduces bleeding and mortality compared to heparin monotherapy

Next Post

#VisualAbstract: Double sequential external defibrillation and vector-change defibrillation improve outcomes in patients with refractory ventricular fibrillation

RelatedReports

All Specialties

Minimally invasive surgery is beneficial for epithelial ovarian cancer 

July 4, 2025
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind June 30, 2025

June 30, 2025
Pediatrics

Evaluating scar outcomes in pediatric burn patients following skin grafting 

June 26, 2025
Survival greater in cervical cancer patients undergoing abdominal hysterectomy compared to minimally invasive techniques: the LACC trial
Weekly Rewinds

2 Minute Medicine Rewind June 16, 2025

June 16, 2025
Next Post
#VisualAbstract: Double sequential external defibrillation and vector-change defibrillation improve outcomes in patients with refractory ventricular fibrillation

#VisualAbstract: Double sequential external defibrillation and vector-change defibrillation improve outcomes in patients with refractory ventricular fibrillation

ACP offers recommendations to improve the ACA, patient care

Parent decision making in poor-prognosis childhood cancer may extend beyond values and preferences

Risk of autism in offspring linked to maternal pregestational diabetes and severe obesity

  Vitamin C supplementation in pregnancy improves respiratory function in children of smoking mothers at 5 years of age

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Seventh cervical nerve neurotomy may augment speech therapy in patients with chronic aphasia post-stroke
  • Time-restricted eating does not confer changes in sleep, mood, or quality of life
  • Commonly cited medication triggers may not increase risk of microscopic colitis among older adults
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.