Tag: nephrology

1. In a retrospective cohort study, several pre-operative and operative factors were found to be associated with acute kidney injury and future mortality. Evidence Rating Level: 2 (Good) Acute kidney injury (AKI) is a significant cause of morality amongst hospitalized patients, especially those undergoing cardiac surgery (CS). This study sought...

Risk factors for acute kidney injury and mortality in high risk patients undergoing cardiac surgery 1. In a retrospective cohort study, several pre-operative and operative factors were found to be associated with acute kidney injury and future mortality. Evidence Rating Level: 2 (Good) Acute kidney injury (AKI) is a significant cause...

1. Individuals with bipolar disorder at higher risk of chronic kidney disease after lithium initiation include patients who are young, female, obese, have high LDL cholesterol, and have lower baseline eGFR levels. Evidence Rating Level: 2 (Good) Lithium is the standard first-line treatment for bipolar disorder worldwide. However, due to its...

1. The median number of RRT-free days was 12 days (IQR 0-25) in the delayed strategy and 10 days (IQR 0-24) in the more-delayed strategy. 2. Hazard ratio for mortality at day 60 was 1.65 in the more-delayed strategy. Evidence Rating Level: 1 (Excellent) Study Rundown: Uncertainty exists regarding the duration for...

1. Patients with end-stage kidney disease were at increased risk of COVID-19-related mortality, particularly among non-Hispanic Black patients. Evidence Rating Level: 3 (Average) End-stage kidney disease (ESKD) has been a significant contributor to COVID-19 mortality, with global fatality estimates falling between 20 to 30% of COVID-19 patients with ESKD. This retrospective...

1. Direct oral anticoagulants may have a superior risk-benefit profile compared to vitamin K antagonists in atrial fibrillation for patients with hemodialysis. Evidence Rating Level: 2 (Good) While direct oral anticoagulants (DOACs) have been shown to have superior risk-benefit profiles over vitamin K antagonists (VKAs) in patients with atrial fibrillation and...

1. Lung transplant patients showed improved renal function and reduced immunosuppressant dosage after twelve months of everolimus treatment. 2. Patients with chronic lung allograft dysfunction showed either sustained or worsened lung function depending on phenotype. Evidence Rating Level: 2 (Good) Following a lung transplant, two factors which reduce survival are graft failure...

1. There is no association between ACE inhibitor or ARB use compared with other antihypertensives for risk of COVID-19 hospitalization for outpatients. 2. There is no association between ACE inhibitor or ARB use compared with other antihypertensives for increased mortality risk in patients hospitalized with diagnosis of COVID-19. Evidence...

Diagnosis and treatment of iron deficiency in heart failure: OFICSel study by the French Heart Failure Working Group 1. Cardiologists were under-testing, against guidelines, for iron deficiency in heart failure patients, likely resulting in under-diagnosing and under-treatment. Evidence Rating Level: 2 (Good) One in every two patients with heart failure (HF) also...

1. Acute kidney injury (AKI) was common among individuals in Mexico with COVID-19 pneumonia. 2. Risk factors for developing AKI were older age, obesity, and need for invasive mechanical ventilation upon admission. Evidence Rating Level: 3 (Average) Individuals testing positive for COVID-19 present with a wide range of comorbidities. COVID-19 pneumonia and...