Tag: antibiotic resistance
1. 100% of children with low-risk symptoms such as rash and itching were negative for true penicillin allergies after 3-tier testing.
2. Rash and itching were reported to be the most common reactions misclassified as penicillin allergies by parents.
Evidence rating level: 4 (Below Average)
Study Rundown: Although penicillin is the most...
1. Behavioral interventions, particular accountable justification and peer comparison, reduced inappropriate antibiotic prescription among primary care physicians to a greater extent than education and observation alone.
2. Rates of return visits were nearly identical between all intervention groups.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Antibiotic over-prescription increases unnecessary health care costs,...
1. Uncomplicated urinary tract infections are a commonly encountered complaint and account for a significant proportion of antibiotic prescriptions.
2. This study randomized patients presenting with symptoms of uncomplicated urinary tract infection to symptomatic treatment with ibuprofen or fosfomycin.
3. The ibuprofen group received significantly fewer antibiotic prescriptions in the 28...
1. Nontherapeutic use of antibacterial agents in animals has led to higher prevalence of multidrug resistant bacterial pathogens among consumers.
2. Children are susceptible to contamination with resistant bacteria through contaminated meat products, cross-contaminated fruits, vegetables and fish, and direct environmental exposure to animals.
Technical Report Rundown: Antimicrobial use and overuse has...
1. Pathogens resistant to standard prophylactic antibiotics caused from over one-third to one-half of infections associated with the ten most common surgical procedures and over one-quarter of infections after cancer chemotherapy.
2. A 30% reduction in antibiotic efficacy due to resistance was estimated to cause 120,000 more infections per...
1. This study found that over 90% of carbapenem-resistant Enterobacteriaceae (CRE) cases were reported in patients with prior health care exposures and comorbid conditions.
2. In this study, a low incidence of CRE was noted in the 7 states that were evaluated. This may indicate that recent interventions could be...
1. Parents who were younger than 30 years old, did not attend college, and insured by Medicaid were less likely than older, college-educated, and commercially-insured parents to correctly answer questions about the appropriate use of antibiotics.
2. Medicaid-insured parents were also more likely to request physicians to prescribe antibiotics unnecessarily...
1. In a major Veterans Affairs Medical Center, the interventional campaign, Kicking CAUTI: No Knee-Jerk Antibiotics, was effective at significantly lowering the rates of inappropriate urine cultures ordered and antibiotics prescribed amongst a catheterized population with asymptomatic bacteruria.
2. Neither feat was achieved at the comparison site VA, where the...
1. The newly discovered antibacterial compound teixobactin, isolated from the soil bacteria Eleftheria terrae, targeted cell wall synthesis in gram-positive bacteria without leading to resistant mutants.
2. In three mouse models of bacterial infection, teixobactin showed comparable efficacy to current antibiotics.
Evidence Rating Level: 2 (Good)
Study Rundown: The dual...
1. A significant proportion of antibiotics given at Chinese primary health care clinics were not appropriate prescriptions.
2. Judicious use of antibiotics is essential to preventing propagation of resistant organisms.
Evidence Rating Level: 4 (Below Average)
Study Rundown: Increased use of antibiotics worldwide has undoubtedly improved morbidity and mortality from infectious diseases....