Tag: Beta-blockers

1. Beta-blockers were commonly used in the treatment of coronary artery disease in the 1980s, though prior studies were inconclusive due to limitations in study design and small sample sizes. 2. This was the first large, randomized trial to demonstrate that propranolol significantly reduced mortality after acute myocardial infarction when...
1. Maternal use of β-2-adrenergic receptor (B2AR) agonist drugs was found to be associated with an increased risk for autism spectrum disorder (ASD) in the child. 2. Although having overlapping confidence intervals, point estimates of the ASD risk from longer exposures to B2AR agonists (≥45 days) tended to be higher...
Image: PD 1. After adjustments, use of vasodilators or ß-blockers were significantly associated with increased risk of early and late age-related macular degeneration (AMD), respectively. 2. In particular, oral nitroglycerin use was significantly associated with early AMD. Evidence Rating Level: 2 (Good) Study Rundown: Vasodilators are thought to stimulate the growth of subretinal vessels due to...
Image: PD  1. Beta-blocker use was associated with no significant improvement in major cardiovascular adverse events (MACE) or all-cause mortality in all patients with ischemic heart disease undergoing non-cardiac surgery.  2.  In a sub group of patients with a history of heart failure, there was significant decrease in MACE and all-cause...
Classics Series, Landmark Trials in Medicine
Image: PD 1. Carvedilol significantly reduced mortality from cardiovascular causes and recurrent non-fatal MI. 2. While carvedilol treatment was associated with a 23% relative risk reduction in all-cause mortality, this did not reach statistical significance. 3. These findings are consistent with previous trials exploring the benefits of beta-blockers in managing acute MI. Original...