Earlier genetic testing predicts bilateral mastectomy in young BRCA carriers
1. Across two decades, utilization of bilateral mastectomy increased among BRCA carriers 40 years old or younger with early breast ...
Tag: BRCA mutation
#VisualAbstract: Single-Agent Trabectedin was noninferior to physician’s choice control chemotherapy in recurrent ovarian cancer
Click here to read this study in the Journal of Clinical Oncology ©2024 2 Minute Medicine, Inc. All rights reserved. No ...
Rucaparib compared to standard-of-care chemotherapy showed promising clinical and safe response to treat BRCA1 or BRCA2 mutated, relapsed ovarian carcinoma
1. The median progression-free survival was 7.4 months in the rucaparib group and 5.7 months in the chemotherapy group for ...
![Maternal cell-free DNA sequencing superior to standard aneuploidy screening [CARE Study]](https://www.2minutemedicine.com/wp-content/uploads/2014/02/47-karyotype-350x250.jpg)
BRCA1/2 pathogenic variants are associated with an increased risk of male breast, pancreatic, and stomach cancer.
1. Pathogenic variants of BRCA1 or BRCA2 are associated with an increased risk of pancreatic and stomach cancer in both ...
#VisualAbstract: Salpingo-oophorectomy may reduce short-term risk of breast cancer in women with BRCA1 and BRCA2 variants
Click to read the study in JAMA Oncology.
#VisualAbstract: Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer
1. In women with BRCA-associated, newly diagnosed advanced ovarian cancer, olaparib significantly prolonged progression-free survival (PFS) at three years compared to ...
The SOLO1 trial: Olaparib significantly delays progression of advanced ovarian cancer
1. In women with BRCA-associated, newly diagnosed advanced ovarian cancer, olaparib significantly prolonged progression-free survival (PFS) at three years compared ...
BRCA1 mutation linked to lower AMH levels
1. Women with a BRCA1 mutation had lower anti-Müllerian hormone (AMH) levels than non-carriers. 2. There was no association between ...
![Reduced neuronal BRCA1 associated with decreased DNA repair in Alzheimer’s disease [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2015/12/DNA_Furchen_edited-350x250.png)
Reduced neuronal BRCA1 associated with decreased DNA repair in Alzheimer’s disease [PreClinical]
1. In a pre-clinical study of post-mortem brains of Alzheimer’s disease (AD) patients, there was an isolated depletion of neuronal ...
2 Minute Medicine Rewind April 19 – April 26, 2015
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Pembrolizumab ...
