Tag: Cardiac surgery

1. The use of intraoperative dexamethasone in infants undergoing elective cardiac surgery with cardiopulmonary bypass did not significantly reduce major complications or mortality compared to placebo. 2. While most outcomes were comparable between the two groups, mean blood glucose levels were higher in the dexamethasone group 24 hours post-surgery.  Evidence Rating...

1. The use of fibrinogen concentrate for fibrinogen replacement, post cardiac surgery, is noninferior to cryoprecipitate. Evidence Rating Level: 1 (Excellent) Study Rundown: A common postoperative complication with cardiac surgery is excessive bleeding which consequently requires blood component transfusion.  The guidelines for the management of cardiac surgery-associated bleeding presenting with acquired hypofibrinogenemia recommend...

1. The use of fibrinogen concentrate for fibrinogen replacement, post cardiac surgery, is noninferior to cryoprecipitate. Evidence Rating Level: 1 (Excellent) Study Rundown: A common postoperative complication with cardiac surgery is excessive bleeding which consequently requires blood component transfusion.  The guidelines for the management of cardiac surgery-associated bleeding presenting with acquired...

1. Compared with placebo, levosimendan did not reduce the need for prolonged catecholamine infusion, use of left ventricular assist device, or renal replacement therapy in patients with low ejection fraction undergoing coronary artery bypass grafting with cardiopulmonary bypass Evidence Rating Level: 1 (Excellent) Study Rundown: Mortality after coronary artery bypass grafting...

1. Levosimendan was not associated with a significant mortality benefit in cardiac surgery patients with perioperative ventricular dysfunction compared to placebo. 2. No significant differences were found in other secondary endpoints including duration of mechanical ventilation, intensive care unit (ICU) stay, hospital stay, or serious adverse events. Evidence Rating Level: 1...

1. There has been almost a 50% decrease in the 30-day mortality of United Kingdom (UK) pediatric cardiac surgery patients over a 10 year period in all but the highest risk surgeries. 2. The total amount of pediatric cardiac surgeries performed in the UK has almost doubled, mainly in the...

1. Fenoldopam did not significantly improve mortality or reduce dialysis initiation in patients with acute kidney injury (AKI) after cardiac surgery. 2. The patients receiving fenoldopam had significantly higher rates of hypotension than the control group. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute kidney injury (AKI) is a common post-operative complication after cardiac...

1. Cardiac allografts without the CCL2 chemokine demonstrated increased graft survival time when compared with wild type (WT) allografts in a mouse model of antibody-mediated rejection (AMR).  2. Markers of AMR including infiltration of classically activated host macrophages, donor-reactive antibody response, and intragraft inflammatory chemokine and cytokine expression were decreased...

Image: PD  1. Remote ischemic preconditioning in CABG patients decreased myocardial injury in the first 72 hours after surgery. 2. All-cause mortality and rates of major adverse cardiac and cerebrovascular outcomes were significantly lower in patients that underwent remote ischemic preconditioning compared to those that did not.  Evidence Rating Level:  2 (Good) Study...

Image: PD  1. Patients who underwent coronary artery bypass graft (CABG) for moderate functional ischemic mitral regurgitation (MR) had similar improvement to those that received CABG plus downsizing annuloplasty. 2. Although CABG plus annuloplasty initially showed greater improvement in mitral regurgitation than CABG alone, outcomes converged over time.  Evidence Rating Level: 3...